VAV1 cdna clone
VAV1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Uniprot Description
VAV1: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation.
Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytosol; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: phosphoinositide-mediated signaling; platelet activation; positive regulation of apoptosis; regulation of cell size; regulation of GTPase activity; regulation of phosphoinositide 3-kinase cascade; regulation of small GTPase mediated signal transduction; T cell costimulation; vascular endothelial growth factor receptor signaling pathway
Research Articles on VAV1
Similar Products
Product Notes
The VAV1 vav1 (Catalog #AAA1273575) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgattgtgc taccactgta ctccagactg gacaaaagat tcctgtgcct taagaacatt agaaccttcc tgtccacctg ctgtgagaag ttcggcctca agcggagcga gctcttcgaa gcctttgacc tcttcgatgt gcaggatttt ggcaaggtca tctacaccct gtctgctctg tcctggaccc cgatcgccca gaacaggggg atcatgccct tccccaccga ggaggagagt gtaggtgatg aagacatcta cagtggcctg tccgaccaga tcgacgacac ggtggaggag gatgaggacc tgtatgactg cgtggagaat gaggaggcgg aaggcgacga gatctatgag gacctcatgc gctcggagcc cgtgtccatg ccgcccaaga tgacagagta tgacaagcgc tgctgctgcc tgcgggagat ccagcagacg gaggagaagt acactgacac gctgggctcc atccagcagc atttcttgaa gcccctgcaa cggttcctga aacctcaaga cattgagatc atctttatca acattgagga cctgcttcgt gttcatactc acttcctaaa ggagatgaag gaagccctgg gcacccctgg cgcagccaat ctctaccagg tcttcatcaa atacaaggag aggttcctcg tctatggccg ctactgcagc caggtggagt cagccagcaa acacctggac cgtgtggccg cagcccggga ggacgtgcag atgaagctgg aggaatgttc tcagagagcc aacaacggga ggttcaccct gcgggacctg ctgatggtgc ctatgcagcg agttctcaaa tatcacctcc ttctccagga gctggtgaaa cacacgcagg aggcgatgga gaaggagaac ctgcggctgg ccctggatgc catgagggac ctggctcagt gcgtgaacga ggtcaagcga gacaacgaga cactgcgaca gatcaccaat ttccagctgt ccattgagaa cctggaccag tctctggctc actatggccg gcccaagatc gacggggaac tcaagatcac ctcggtggaa cggcgctcca agatggacag gtatgccttc ctgctcgaca aagctctact catctgtaag cgcaggggag actcctatga cctcaaggac tttgtaaacc tgcacagctt ccaggttcgg gatgactctt caggagaccg agacaacaag aagtggagcc acatgttcct cctgatcgag gaccaaggtg cccagggcta tgagctgttc ttcaagacaa gagaattgaa gaagaagtgg atggagcagt ttgagatggc catctccaac atctatccgg agaatgccac cgccaacggg catgacttcc agatgttctc ctttgaggag accacatcct gcaaggcctg tcagatgctg cttagaggta ccttctatca gggctaccgc tgccatcggt gccgggcatc tgcacacaag gagtgtctgg ggagggtccc tccatgtggc cgacatgggc aagatttccc aggaactatg aagaaggaca aactacatcg cagggctcag gacaaaaaga ggaatgagct gggtctgccc aagatggagg tgtttcagga atactacggg cttcctccac cccctggagc cattggaccc tttctacggc tcaaccctgg agacattgtg gagctcacga aggctgaggc tgaacagaac tggtgggagg gcagaaatac atctactaat gaaattggct ggtttccttg taacagggtg aagccctatg tccatggccc tcctcaggac ctgtctgttc atctctggta cgcaggcccc atggagcggg caggggcaga gagcatcctg gccaaccgct cggacgggac tttcttggtg cggcagaggg tgaaggatgc agcagaattt gccatcagca ttaaatataa cgtcgaggtc aagcacatta aaatcatgac agcagaagga ctgtaccgga tcacagagaa aaaggctttc cgggggctta cggagctggt ggagttttac cagcagaact ctctaaagga ttgcttcaag tctctggaca ccaccttgca gttccccttc aaggagcctg aaaagagaac catcagcagg ccagcagtgg gaagcacaaa gtattttggc acagccaaag cccgctatga cttctgcgcc cgagaccgat cagagctgtc gctcaaggag ggtgacatca tcaagatcct taacaagaag ggacagcaag gctggtggcg aggggagatc tatggccggg ttggctggtt ccctgccaac tacgtggagg aagattattc tgaatactgc tga. It is sometimes possible for the material contained within the vial of "VAV1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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