ASTL cdna clone
ASTL cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
ASTL: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. Belongs to the peptidase M12A family.
Protein type: Protease; EC 3.4.-.-
Chromosomal Location of Human Ortholog: 2q11.1
Cellular Component: cytoplasm; plasma membrane
Molecular Function: metalloendopeptidase activity; peptidase activity
Biological Process: cell adhesion; fertilization; proteolysis