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ASTL cdna clone

ASTL cDNA Clone

Gene Names
ASTL; SAS1B
Synonyms
ASTL; ASTL cDNA Clone; ASTL cdna clone
Ordering
 
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For Research Use Only!
Sequence
ATGGAGGGTGTAGGGGGTCTCTGGCCTTGGGTGCTGGGTCTGCTCTCCTTGCCAGGTGTGATCCTAGGAGCGCCCCTGGCCTCCAGCTGCGCAGGAGCCTGTGGTACCAGCTTCCCAGATGGCCTCACCCCTGAGGGAACCCAGGCCTCCGGGGACAAGGACATTCCTGCAATTAACCAAGGGCTCATCCTGGAAGAAACCCCAGAGAGCAGCTTCCTCATCGAGGGGGACATCATCCGGCCGAGTCCCTTCCGACTGCTGTCAGCAACCAGCAACAAATGGCCCATGGGTGGTAGTGGTGTCGTGGAGGTCCCCTTCCTGCTCTCCAGCAAGTACGATGAGCCCAGCCGCCAGGTCATCCTGGAGGCTCTTGCGGAGTTTGAACGTTCCACGTGCATCAGGTTTGTCACCTATCAGGACCAGAGAGACTTCATTTCCATCATCCCCATGTATGGGTGCTTCTCGAGTGTGGGGCGCAGTGGAGGGATGCAGGTGGTCTCCCTGGCGCCCACGTGTCTCCAGAAGGGCCGGGGCATTGTCCTTCATGAGCTCATGCATGTGCTGGGCTTCTGGCACGAGCACACGCGGGCCGACCGGGACCGCTATATCCGTGTCAACTGGAACGAGATCCTGCCAGGCTTTGAAATCAACTTCATCAAGTCTCGGAGCAGCAACATGCTGACGCCCTATGACTACTCCTCTGTGATGCACTATGGGAGGCTTGCCTTCAGCCGGCGTGGGCTGCCCACCATCACACCACTTTGGGCCCCCAGTGTCCACATCGGCCAGCGATGGAACCTGAGTGCCTCGGACATCACCCGGGTCCTCCAACTCTACGGCTGCAGCCCAAGTGGCCCCAGGCCCCGTGGGAGAGGGTCCCATGCCCACAGCACTGGTAGGAGCCCCGCTCCGGCCTCCCTATCTCTGCAGCGGCTTTTGGAGGCACTGTCGGCGGAATCCAGGAGCCCCGACCCCAGTGGTTCCAGTGCGGGAGGCCAGCCCGTTCCTGCAGGGCCTGGGGAGAGCCCACATGGGTGGGAGTCCCCTGCCCTGAAAAAGCTCAGTGCAGAGGCCTCGGCAAGGCAGCCTCAGACCCTGGCTTCCTCCCCAAGATCAAGGCCTGGAGCAGGTGCCCCCGGTGTTGCTCAGGAGCAGTCCTGGCTGGCCGGAGTGTCCACCAAGCCCACAGTCCCATCTTCAGAAGCAGGAATCCAGCCAGTCCCTGTCCAGGGAAGCCCAGCTCTGCCAGGGGGCTGTGTACCTAGAAATCATTTCAAGGGGATGTCCGAAGATTAA
Sequence Length
1296
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
45,936 Da
NCBI Official Full Name
Homo sapiens astacin-like metallo-endopeptidase (M12 family), mRNA
NCBI Official Synonym Full Names
astacin like metalloendopeptidase
NCBI Official Symbol
ASTL
NCBI Official Synonym Symbols
SAS1B
NCBI Protein Information
astacin-like metalloendopeptidase
UniProt Protein Name
Astacin-like metalloendopeptidase
Protein Family
UniProt Gene Name
ASTL
UniProt Entry Name
ASTL_HUMAN

Uniprot Description

ASTL: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. Belongs to the peptidase M12A family.

Protein type: Protease; EC 3.4.-.-

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: metalloendopeptidase activity; peptidase activity

Biological Process: cell adhesion; fertilization; proteolysis

Research Articles on ASTL

1. The SAS1B metalloproteinase is proposed as a prototype cancer-oocyte tumor surface neoantigen for development of targeted immunotherapeutics with limited on-target/off tumor effects predicted to be restricted to the population of growing oocytes.

Similar Products

ASTL Antibody

Host: Rabbit
Reactivity: Human
Apps: ELISA, Western Blot

ASTL Antibody

Host: Rabbit
Reactivity: Human
Apps: ELISA, Immunohistochemistry

ASTL Antibody

Host: Rabbit
Reactivity: Human. Predicted: Mouse, Rat
Apps: ELISA, Western Blot

ASTL Antibody

Host: Rabbit
Reactivity: Human
Predicted: Mouse, Rat
Apps: ELISA, Western Blot

Product Notes

The ASTL astl (Catalog #AAA1273515) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGGGTG TAGGGGGTCT CTGGCCTTGG GTGCTGGGTC TGCTCTCCTT GCCAGGTGTG ATCCTAGGAG CGCCCCTGGC CTCCAGCTGC GCAGGAGCCT GTGGTACCAG CTTCCCAGAT GGCCTCACCC CTGAGGGAAC CCAGGCCTCC GGGGACAAGG ACATTCCTGC AATTAACCAA GGGCTCATCC TGGAAGAAAC CCCAGAGAGC AGCTTCCTCA TCGAGGGGGA CATCATCCGG CCGAGTCCCT TCCGACTGCT GTCAGCAACC AGCAACAAAT GGCCCATGGG TGGTAGTGGT GTCGTGGAGG TCCCCTTCCT GCTCTCCAGC AAGTACGATG AGCCCAGCCG CCAGGTCATC CTGGAGGCTC TTGCGGAGTT TGAACGTTCC ACGTGCATCA GGTTTGTCAC CTATCAGGAC CAGAGAGACT TCATTTCCAT CATCCCCATG TATGGGTGCT TCTCGAGTGT GGGGCGCAGT GGAGGGATGC AGGTGGTCTC CCTGGCGCCC ACGTGTCTCC AGAAGGGCCG GGGCATTGTC CTTCATGAGC TCATGCATGT GCTGGGCTTC TGGCACGAGC ACACGCGGGC CGACCGGGAC CGCTATATCC GTGTCAACTG GAACGAGATC CTGCCAGGCT TTGAAATCAA CTTCATCAAG TCTCGGAGCA GCAACATGCT GACGCCCTAT GACTACTCCT CTGTGATGCA CTATGGGAGG CTTGCCTTCA GCCGGCGTGG GCTGCCCACC ATCACACCAC TTTGGGCCCC CAGTGTCCAC ATCGGCCAGC GATGGAACCT GAGTGCCTCG GACATCACCC GGGTCCTCCA ACTCTACGGC TGCAGCCCAA GTGGCCCCAG GCCCCGTGGG AGAGGGTCCC ATGCCCACAG CACTGGTAGG AGCCCCGCTC CGGCCTCCCT ATCTCTGCAG CGGCTTTTGG AGGCACTGTC GGCGGAATCC AGGAGCCCCG ACCCCAGTGG TTCCAGTGCG GGAGGCCAGC CCGTTCCTGC AGGGCCTGGG GAGAGCCCAC ATGGGTGGGA GTCCCCTGCC CTGAAAAAGC TCAGTGCAGA GGCCTCGGCA AGGCAGCCTC AGACCCTGGC TTCCTCCCCA AGATCAAGGC CTGGAGCAGG TGCCCCCGGT GTTGCTCAGG AGCAGTCCTG GCTGGCCGGA GTGTCCACCA AGCCCACAGT CCCATCTTCA GAAGCAGGAA TCCAGCCAGT CCCTGTCCAG GGAAGCCCAG CTCTGCCAGG GGGCTGTGTA CCTAGAAATC ATTTCAAGGG GATGTCCGAA GATTAA. It is sometimes possible for the material contained within the vial of "ASTL, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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