PAM cdna clone
PAM cDNA Clone
Gene Names
PAM; PAL; PHM
Synonyms
PAM; PAM cDNA Clone; PAM cdna clone
Sequence
atggctggccgcgtccctagcctgctagttctccttgtttttccaagcagctgtttggctttccgaagcccactttctgtctttaagaggtttaaagaaactaccagaccattttccaatgaatgtcttggtaccaccagacccgtagttcctattgattcatcagattttgcattggatattcgcatgcctggggttacacctaaacagtccgatacatacttctgcatgtctatgcgaataccagtggatgaggaagccttcgtgattgacttcaagcctcgagccagcatggatactgtccatcacatgttactttttggatgcaatatgccttcatccactggaagttactggttttgtgatgaaggaacctgtacagataaagccaatattctgtatgcctgggcgagaaatgctccccctacccggctccccaaaggtgttggattcagagttggaggagagactggaagtaaatactttgtactacaggtacactatggggatattagtgcttttagagataataacaaggactgttctggtgtgtccttacacctcacacgtctgccacagcctttaattgctggcatgtaccttatgatgtctgttgacactgttatcccagcaggagaaaaagtggtgaattctgacatttcatgccattataaaaattatccaatgcatgtctttgcctatagagttcacactcaccatttaggtaaggtagtaagtggatacagagtaagaaatggacagtggacactgattggacggcagagccctcagctgccacaggctttctaccctgtggggcatccagttgatgtaagttttggtgacctactggctgcaagatgtgtattcactggtgaaggaaggacagaagccacacacattggtggcacgtctagtgatgaaatgtgcaacttatacattatgtattacatggaagccaagcatgcagtttctttcatgacctgtacccagaatgtagctccagatatgttcagaaccataccaccagaggccaacattccaattcccgtgaagtctgatatggttatgatgcatgaacatcataaagaaacagaatataaagataagattcctttactacagcagccaaaacgagaagaagaagaagtgttagaccaggatttccacatggaagaggcactggattggcctggagtatacttgttaccaggccaggtttctggggtggctctagaccctaagaataacctggtgattttccacagaggtgaccatgtctgggatggaaactcgtttgacagcaagtttgtttaccagcaaataggactcggaccaattgaagaagacactattcttgtcatagatccaaataatgctgcagtactccagtccagtggaaaaaatctgttttacttgccacatggcttgagtatagataaagatgggaattattgggtcacagacgtggctctccatcaggtgttcaaactggatccaaacaataaagaaggccctgtattaatcctgggaaggagcatgcaaccaggcagtgaccagaatcacttctgtcaacccactgatgtggctgtggatccaggcactggagccatttatgtatcagatggttactgcaacagcaggattgtgcagttttcaccaagtggaaagttcatcacacagtggggagaagagtcttcagggagcagtcctctgccaggccagttcactgttcctcacagcttggctcttgtgcctcttttgggccaattatgtgtggcagaccgggaaaatggtcggatccagtgttttaaaactgacaccaaagaatttgtgagagagattaagcattcatcatttggaagaaatgtatttgcaatttcatatataccaggcttgctctttgcagtgaatgggaagcctcattttggggaccaagaacctgtacaaggatttgtgatgaacttttccaatggggaaattatcgacatcttcaagccagtgcgcaagcactttgatatgcctcatgatattgttgcatctgaagatgggactgtgtacattggagatgctcataccaacaccgtgtggaagttcaccttgactgagaaattggaacatcgatcagttaaaaaggctggcattgaggtccaggaaatcaaagaagccgaggcagttgttgaaaccaaaatggagaacaaacccacctcctcagaattgcagaagatgcaagagaaacagaaactgatcaaagagccaggctcgggagtgcctgttgttctcattacaacccttctggttattccggtggttgtcctgctggccattgccatatttattcggtggaaaaaatcaagggcctttggagattctgaacacaaactcgagacgagttcaggaagagtactgggaagatttagaggaaagggaagtggaggcttaaaccttggtaatttctttgcaagccgtaagggctacagtcgaaaagggtttgaccggcttagcactgagggcagtgaccaagagaaagaggatgatggaagtgaatcagaagaggagtattcagcacctctgcctgcgctcgcaccttcctcctcctga
Sequence Length
2601
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
106,276 Da
NCBI Official Full Name
Homo sapiens peptidylglycine alpha-amidating monooxygenase, mRNA
NCBI Official Synonym Full Names
peptidylglycine alpha-amidating monooxygenase
NCBI Official Symbol
PAM
NCBI Official Synonym Symbols
PAL; PHM
NCBI Protein Information
peptidyl-glycine alpha-amidating monooxygenase
UniProt Protein Name
Peptidyl-glycine alpha-amidating monooxygenase
Protein Family
UniProt Gene Name
PAM
UniProt Synonym Gene Names
PAM; PHM; PAL
UniProt Entry Name
AMD_HUMAN
NCBI Description
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Description
PAM: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.17.3; EC 4.3.2.5; Membrane protein, integral; Vesicle; Lyase; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q14-q21
Cellular Component: membrane
Molecular Function: peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; protein binding; zinc ion binding
Biological Process: peptide amidation
Research Articles on PAM
Similar Products
Product Notes
The PAM pam (Catalog #AAA1273068) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctggcc gcgtccctag cctgctagtt ctccttgttt ttccaagcag ctgtttggct ttccgaagcc cactttctgt ctttaagagg tttaaagaaa ctaccagacc attttccaat gaatgtcttg gtaccaccag acccgtagtt cctattgatt catcagattt tgcattggat attcgcatgc ctggggttac acctaaacag tccgatacat acttctgcat gtctatgcga ataccagtgg atgaggaagc cttcgtgatt gacttcaagc ctcgagccag catggatact gtccatcaca tgttactttt tggatgcaat atgccttcat ccactggaag ttactggttt tgtgatgaag gaacctgtac agataaagcc aatattctgt atgcctgggc gagaaatgct ccccctaccc ggctccccaa aggtgttgga ttcagagttg gaggagagac tggaagtaaa tactttgtac tacaggtaca ctatggggat attagtgctt ttagagataa taacaaggac tgttctggtg tgtccttaca cctcacacgt ctgccacagc ctttaattgc tggcatgtac cttatgatgt ctgttgacac tgttatccca gcaggagaaa aagtggtgaa ttctgacatt tcatgccatt ataaaaatta tccaatgcat gtctttgcct atagagttca cactcaccat ttaggtaagg tagtaagtgg atacagagta agaaatggac agtggacact gattggacgg cagagccctc agctgccaca ggctttctac cctgtggggc atccagttga tgtaagtttt ggtgacctac tggctgcaag atgtgtattc actggtgaag gaaggacaga agccacacac attggtggca cgtctagtga tgaaatgtgc aacttataca ttatgtatta catggaagcc aagcatgcag tttctttcat gacctgtacc cagaatgtag ctccagatat gttcagaacc ataccaccag aggccaacat tccaattccc gtgaagtctg atatggttat gatgcatgaa catcataaag aaacagaata taaagataag attcctttac tacagcagcc aaaacgagaa gaagaagaag tgttagacca ggatttccac atggaagagg cactggattg gcctggagta tacttgttac caggccaggt ttctggggtg gctctagacc ctaagaataa cctggtgatt ttccacagag gtgaccatgt ctgggatgga aactcgtttg acagcaagtt tgtttaccag caaataggac tcggaccaat tgaagaagac actattcttg tcatagatcc aaataatgct gcagtactcc agtccagtgg aaaaaatctg ttttacttgc cacatggctt gagtatagat aaagatggga attattgggt cacagacgtg gctctccatc aggtgttcaa actggatcca aacaataaag aaggccctgt attaatcctg ggaaggagca tgcaaccagg cagtgaccag aatcacttct gtcaacccac tgatgtggct gtggatccag gcactggagc catttatgta tcagatggtt actgcaacag caggattgtg cagttttcac caagtggaaa gttcatcaca cagtggggag aagagtcttc agggagcagt cctctgccag gccagttcac tgttcctcac agcttggctc ttgtgcctct tttgggccaa ttatgtgtgg cagaccggga aaatggtcgg atccagtgtt ttaaaactga caccaaagaa tttgtgagag agattaagca ttcatcattt ggaagaaatg tatttgcaat ttcatatata ccaggcttgc tctttgcagt gaatgggaag cctcattttg gggaccaaga acctgtacaa ggatttgtga tgaacttttc caatggggaa attatcgaca tcttcaagcc agtgcgcaag cactttgata tgcctcatga tattgttgca tctgaagatg ggactgtgta cattggagat gctcatacca acaccgtgtg gaagttcacc ttgactgaga aattggaaca tcgatcagtt aaaaaggctg gcattgaggt ccaggaaatc aaagaagccg aggcagttgt tgaaaccaaa atggagaaca aacccacctc ctcagaattg cagaagatgc aagagaaaca gaaactgatc aaagagccag gctcgggagt gcctgttgtt ctcattacaa cccttctggt tattccggtg gttgtcctgc tggccattgc catatttatt cggtggaaaa aatcaagggc ctttggagat tctgaacaca aactcgagac gagttcagga agagtactgg gaagatttag aggaaaggga agtggaggct taaaccttgg taatttcttt gcaagccgta agggctacag tcgaaaaggg tttgaccggc ttagcactga gggcagtgac caagagaaag aggatgatgg aagtgaatca gaagaggagt attcagcacc tctgcctgcg ctcgcacctt cctcctcctg a. It is sometimes possible for the material contained within the vial of "PAM, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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