ALDH3A2 cdna clone
ALDH3A2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial; Secondary Metabolites Metabolism - limonene and pinene degradation; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - histidine; Oxidoreductase; EC 1.2.1.3; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - arginine and proline; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - glycerolipid; Membrane protein, integral; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; peroxisomal membrane
Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; long-chain-alcohol oxidase activity
Biological Process: aldehyde metabolic process; central nervous system development; epidermis development; fatty acid alpha-oxidation; peripheral nervous system development; phytol metabolic process; sphingolipid biosynthetic process
Disease: Sjogren-larsson Syndrome
Research Articles on ALDH3A2
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Product Notes
The ALDH3A2 aldh3a2 (Catalog #AAA1272839) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagctcg aagtccggcg ggtccgacag gcgttcctgt ccggccggtc gcgacctctg cggtttcggc tgcagcagct ggaggccctg cggaggatgg tgcaggagcg cgagaaggat atcctgacgg ccatcgccgc cgacctgtgc aagagtgaat tcaatgtgta cagtcaggaa gtcattactg tccttgggga aattgatttt atgcttgaga atcttcctga atgggttact gctaaaccag ttaagaagaa cgtgctcacc atgctggatg aggcctatat tcagccacag cctctgggag tggtgctgat aatcggagct tggaattacc ccttcgttct caccattcag ccactgatag gagccatcgc tgcaggaaat gctgtgatta taaagccttc tgaactgagt gaaaatacag ccaagatctt ggcaaagctt ctccctcagt atttagacca ggatctctat attgttatta atggtggtgt tgaggaaacc acggagctcc tgaagcagcg atttgaccac attttctata cgggaaacac tgcggttggc aaaattgtca tggaagctgc tgccaagcat ctgacccctg tgactcttga actgggaggg aaaagtccat gttatattga taaagattgt gacctggaca ttgtttgcag acgcataacc tggggaaaat acatgaattg tggccaaacc tgcattgcac ccgactatat tctctgtgaa gcatccctcc aaaatcaaat tgtatggaag attaaggaaa cagtgaagga attttatgga gaaaatataa aagagtctcc tgattatgaa aggatcatca atcttcgtca ttttaagagg atactaagtt tgcttgaagg acaaaagata gcttttggtg gggagactga tgaggccaca cgctacatag ccccaacagt acttaccgat gttgatccta aaaccaaggt gatgcaagaa gaaatttttg gaccaattct tccaatagtg cctgtgaaaa atgtagatga ggccataaat ttcataaatg aacgtgaaaa gcctctggct ctttatgtat tttcgcataa ccataagctc atcaaacgga tgattgatga gacatccagt ggaggtgtca caggcaatga cgtcattatg cacttcacgc tcaactcttt cccatttgga ggagtgggtt ccagtgggat gggagcttat cacggaaaac atagttttga tactttttct catcagcgtc cctgtttatt aaaaagttta aagagagaag gtgctaacaa actcagatat cctcccaaca gccagtcaaa ggtggattgg ggaaaatttt ttctcttgaa acggttcaac aaagaaaaac tcggtctcct gttgctcact ttcctgggta ttgtagccgc tgtgcttgtc aagaaatacc aagctgtgct gaggagaaag gccctgttga tttttctggt agttcacaga ctgcgttggt ccagtaagca gagatga. It is sometimes possible for the material contained within the vial of "ALDH3A2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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