MRAP2 cdna clone
MRAP2 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
MRAP2: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Belongs to the MRAP family. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R
Chromosomal Location of Human Ortholog: 6q14.2
Cellular Component: endoplasmic reticulum; plasma membrane
Molecular Function: adrenocorticotropin hormone receptor binding; identical protein binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor binding
Biological Process: energy reserve metabolic process; feeding behavior; positive regulation of cAMP biosynthetic process
Disease: Body Mass Index Quantitative Trait Locus 18
Research Articles on MRAP2
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Product Notes
The MRAP2 mrap2 (Catalog #AAA1272684) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccgccc agaggttaat ttctaacaga acctcccagc aatcggcatc taattctgat tacacctggg aatatgaata ttatgagatt ggaccagttt cctttgaagg actgaaggct cataaatatt ccattgtgat tggattttgg gttggtcttg cagtcttcgt gatttttatg ttttttgtgc tgaccttgct gaccaagaca ggagccccac accaagacaa tgcagagtcc tcagagaaga gattcagaat gaacagcttt gtgtcagact ttggaagacc tctggagcca gataaagtat tttctcgcca aggcaacgag gagtccaggt ctctctttca ctgctacatc aatgaggtgg aacgcttgga cagagccaaa gcttgtcacc agaccacagc ccttgacagt gacgtccaac tccaggaagc catcagaagc agtgggcagc cagaggagga gctgaacagg ctcatgaagt ttgacatccc caactttgtg aacacagacc agaactactt tggggaggat gatcttctga tttctgaacc acctattgtt ctggaaacta agccactttc ccagacctca cacaaagacc tggattga. It is sometimes possible for the material contained within the vial of "MRAP2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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