BPHL cdna clone
BPHL cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Uniprot Description
BPHL: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: mitochondrial outer membrane; mitochondrion
Molecular Function: alpha-amino-acid esterase activity; hydrolase activity
Biological Process: amino acid metabolic process; response to toxin; xenobiotic metabolic process
Research Articles on BPHL
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Product Notes
The BPHL bphl (Catalog #AAA1272526) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCCCAGGA ATCTGCTTTA TTCTCTTTTG TCCTCCCACC TGTCCCCCCA TTTCAGCACC TCGGTAACCT CTGCCAAAGT GGCTGTGAAT GGCGTTCAGC TGCATTACCA GCAGACTGGA GAGGGAGATC ACGCAGTCCT GCTACTTCCT GGGATGTTAG GAAGTGGAGA GACTGATTTT GGACCTCAGC TCAAGAACCT CAATAAGAAG CTCTTCACGG TGGTCGCCTG GGATCCTCGA GGCTATGGAC ATTCCAGGCC CCCAGATCGC GATTTCCCAG CAGACTTTTT TGAAAGGGAT GCAAAAGATG CTGTTGATTT GATGAAGGCG CTGAAGTTTA AGAAGGTTTC TCTGCTGGGG TGGAGTGATG GGGGCATAAC CGCACTCATT GCTGCTGCAA AATATCCATC TTACATCCAC AAGATGGTGA TCTGGGGCGC CAACGCCTAC GTCACTGACG AAGACAGCAT GATATATGAG GGCATCCGAG ATGTTTCCAA ATGGAGTGAG AGAACAAGAA AGCCTCTAGA AGCCCTCTAT GGGTATGACT ACTTTGCCAG AACCTGTGAA AAGTGGGTGG ATGGCATAAG ACAGTTTAAA CATCTCCCAG ATGGTAACAT CTGCCGGCAC CTGCTGCCCC GGGTCCAGTG CCCCGCCTTG ATTGTGCACG GTGAGAAGGA TCCTCTGGTC CCACGGTTTC ATGCCGACTT CATTCATAAG CACGTGAAAG GCTCACGGCT GCATTTGATG CCAGAAGGCA AACACAACCT GCATTTGCGT TTTGCAGATG AATTCAACAA GTTAGCAGAA GACTTCCTAC AATGA. It is sometimes possible for the material contained within the vial of "BPHL, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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