CDK2 cdna clone
CDK2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Description
CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: Cajal body; centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; endosome; nucleoplasm; nucleus
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: centriole replication; centrosome duplication; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA replication; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; meiosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; peptidyl-serine phosphorylation; positive regulation of cell proliferation; Ras protein signal transduction; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Research Articles on CDK2
Similar Products
Product Notes
The CDK2 cdk2 (Catalog #AAA1272308) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagaact tccaaaaggt ggaaaagatc ggagagggca cgtacggagt tgtgtacaaa gccagaaaca agttgacggg agaggtggtg gcgcttaaga aaatccgcct ggacactgag actgagggtg tgcccagtac tgccatccga gagatctctc tgcttaagga gcttaaccat cctaatattg tcaagctgct ggatgtcatt cacacagaaa ataaactcta cctggttttt gaatttctgc accaagatct caagaaattc atggatgcct ctgctctcac tggcattcct cttcccctca tcaagagcta tctgttccag ctgctccagg gcctagcttt ctgccattct catcgggtcc tccaccgaga ccttaaacct cagaatctgc ttattaacac agagggggcc atcaagctag cagactttgg actagccaga gcttttggag tccctgttcg tacttacacc catgaggtgg tgaccctgtg gtaccgagct cctgaaatcc tcctgggctg caaatattat tccacagctg tggacatctg gagcctgggc tgcatctttg ctgagatggt gactcgccgg gccctattcc ctggagattc tgagattgac cagctcttcc ggatctttcg gactctgggg accccagatg aggtggtgtg gccaggagtt acttctatgc ctgattacaa gccaagtttc cccaagtggg cccggcaaga ttttagtaaa gttgtacctc ccctggatga agatggacgg agcttgttat cgcaaatgct gcactacgac cctaacaagc ggatttcggc caaggcagcc ctggctcacc ctttcttcca ggatgtgacc aagccagtac cccatcttcg actctga. It is sometimes possible for the material contained within the vial of "CDK2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
