CMPK2 cdna clone
CMPK2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Description
CMPK2: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Belongs to the thymidylate kinase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, other; Nucleotide Metabolism - pyrimidine; EC 2.7.4.14; EC 2.7.4.6
Chromosomal Location of Human Ortholog: 2p25.2
Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function: cytidylate kinase activity; nucleoside diphosphate kinase activity; thymidylate kinase activity; UMP kinase activity
Biological Process: dTDP biosynthetic process; dTTP biosynthetic process; dUDP biosynthetic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process
Research Articles on CMPK2
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Product Notes
The CMPK2 cmpk2 (Catalog #AAA1272037) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCTTCG CCCGCCGGCT CCTGCGCGGG CCACTGTCGG GGCCGCTGCT CGGGCGGCGC GGGGTCTGCG CTGGGGCCAT GGCTCCGCCG CGCCGCTTCG TCCTGGAGCT TCCCGACTGC ACCCTGGCTC ACTTCGCCCT AGGCGCCGAC GCCCCCGGCG ACGCAGACGC CCCCGACCCC CGCCTGGCGG CGCTGCTGGG GCCCCCGGAG CGCAGCTACT CGCTGTGCGT GCCCGTGACC CCGGACGCCG GCTGCGGGGC CCGGGTCCGG GCGGCGCGGC TGCACCAGCG CCTGCTGCAC CAGCTGCGCC GCGGCCCCTT CCAGCGGTGC CAGCTGCTCA GGCTGCTCTG CTACTGCCCG GGCGGCCAGG CCGGCGGCGC ACAGCAAGGC TTCCTGCTGC GCGACCCCCT GGATGACCCT GACACCCGGC AAGCGCTGCT CGAGCTGCTG GGCGCCTGCC AGGAGGCACC ACGCCCGCAC TTGGGCGAGT TCGAGGCCGA CCCGCGCGGC CAGCTGTGGC AGCGCCTCTG GGAGGTGCAA GACGGCAGGC GGCTGCAGGT GGGCTGCGCA CAGGTCGTGC CCGTCCCGGA GCCCCCGCTG CACCCGGTGG TGCCAGACTT GCCCAGTTCC GTGGTCTTCC CGGACCGGGA AGCCGCCCGG GCCGTTTTGG AGGAGTGTAC CTCCTTTATT CCTGAAGCCC GGGCAGTGCT TGACCTGGTC GACCAGTGCC CAAAACAGAT CCAGAAAGGA AAGTTCCAGG TTGTTGCCAT CGAAGGACTG GATGCCACGG GTAAAACCAC GGTGACCCAG TCAGTGGCAG ATTCACTTAA GGCTGTCCTC TTAAAGTCAC CACCCTCTTG CATTGGCCAG TGGAGGAAGA TCTTTGATGA TGAACCAACT ATCATTAGAA GAGCTTTTTA CTCTTTGGGC AATTATATTG TGGCCTCCGA AATAGCTAAA GAATCTGCCA AATCTCCTGT GATTGTAGAC AGGTACTGGC ACAGCACGGC CACCTATGCC ATAGCCACTG AGGTGAGTGG GGGTCTCCAG CACCTGCCCC CAGCCCATCA CCCTGTGTAC CAGTGGCCAG AGGACCTGCT CAAACCTGAC CTTATCCTGC TGCTCACTGT GAGTCCTGAG GAGAGGTTGC AGAGGCTGCA GGGCCGGGGC ATGGAGAAGA CCAGGGAAGA AGCAGAACTT GAGGCCAACA GTGTGTTTCG TCAAAAGTAG. It is sometimes possible for the material contained within the vial of "CMPK2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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