PHC2 cdna clone
PHC2 cDNA Clone
Gene Names
PHC2; PH2; EDR2; HPH2
Synonyms
PHC2; PHC2 cDNA Clone; PHC2 cdna clone
Sequence
atggagaatgagctgccagtcccacatacatctagcagtgcctgtgccaccagcagtaccagcggggccagtagcagcagtggctgcaacaacagcagcagtggtggaagtggccgccccaccgggccccagatttctgtgtacagtggtattccagaccggcagaccgtgcaggtgatccagcaggccctgcacagacagcccagcacggccgctcagtacctgcagcagatgtacgccgcccagcagcagcacctcatgctgcagaccgcggcgctccagcagcagcacctcagcagcgcccagctccagagcctggcagccgtacagcaggcaagcctggtatccaatagacaaggaagcacttcaggcagcaatgtgtctgcgcaggccccggcccagtcatcttcgatcaacctggcagcctccccagcagcagcccagctcctcaaccgggcccagagtgtgaactctgcagcagcctcaggcatcgctcagcaggctgtgctcttgggcaacacgtcttccccagccctgactgcaagccaagcacagatgtatctgagggcacagatggtacagaacttgaccctccgaacacagcagacaccagcggcagcagcctcgggccccacccccactcagcctgtcctgcccagcttggccctgaaacccacgccgggcggtagccagcctctgcctaccccagcacagagcagaaatactgctcaggcttcccccgcaggtgccaagcctggcatagctgacagtgtgatggagccacacaagaaaggagatggcaacagcagtgtgccagggagcatggaaggccgggctgggctcagccggacggttcctgctgtggctgcccaccccctcattgcaccagcctatgctcagctgcagccacaccagctcctcccacagccatcctcaaagcacctgcagccccaatttgtgatccagcagcagccacagccacaacagcagcagccgccgccccagcagtcacggcctgtgctccaagctgagccccacccccagctcgcctcagtctctccaagcgtggccctccagcccagctcagaggcccatgccatgccactaggcccggttacacccgccctgccactccagtgtcccactgccaacctgcacaagcctggcggcagtcagcagtgtcaccctcccacacctgatactgggcctcagaatggacatcccgagggcgtgccccacacccctcaacgcaggttccagcacacttcagctgtcatcttacaactgcagcctgcttcaccagtgccccagcagtgtgtccctgatgactggaaagaaatggcaccaggggagaaaagtgtgcctgagacgcggtctggcccatcaccacatcagcaggctattgtcactgccatgcctggtggcctgcctgtacccacgagccctaacatccagccgtccccagctcacgagacagggcagggcattgttcatgcactgaccgacctcagcagccccggcatgacctcagggaacggaaactctgcctccagcatcgccggcactgccccccagaatggtgagaataaaccaccacaggccattgtgaaaccccaaatcctgacgcatgttatcgaagggtttgtgatccaggagggggcggagcctttcccggtgggacgctcgtccctgctggtggggaatctcaagaagaagtatgcacaggggttcctgcctgagaaacttccacagcaggatcacaccaccaccactgactcggagatggaggagccctatctgcaagaatccaaagaggagggtgctcccctcaaactcaagtgtgagctctgtggccgggtggactttgcctataagttcaagcgttccaagcgcttctgttccatggcttgtgcaaagaggtacaacgtgggatgcaccaaacgggtgggacttttccactcagaccggagcaagctgcagaaggcaggagctgcgacccacaaccgccgtcgggccagcaaagccagtctgccaccacttaccaaggataccaagaagcagccaacaggcactgtgcccctttcggttactgctgctttgcagctaacacacagccaggaagactccagccgttgctcagataactcaagctatgaggaacccttgtcacccatctcagccagctcatctacttcccgccggcgacaaggccagcgggacctggagctccccgacatgcatatgcgggacctggtgggcatgggacaccacttcctgccaagtgagcccaccaagtggaatgtagaagacgtctacgaattcatccgctctctgccaggctgccaggagatagcagaggaattccgtgcccaggaaatcgacgggcaagccctgctgctgctcaaggaggaccacctgatgagcgccatgaacatcaagctggggcccgccctgaagatctatgcccgcatcagcatgctcaaggactcctag
Sequence Length
2493
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
90,812 Da
NCBI Official Full Name
Homo sapiens polyhomeotic homolog 2 (Drosophila), mRNA
NCBI Official Synonym Full Names
polyhomeotic homolog 2
NCBI Official Symbol
PHC2
NCBI Official Synonym Symbols
PH2; EDR2; HPH2
NCBI Protein Information
polyhomeotic-like protein 2
UniProt Protein Name
Polyhomeotic-like protein 2
Protein Family
UniProt Gene Name
PHC2
UniProt Synonym Gene Names
EDR2; PH2; hPH2
UniProt Entry Name
PHC2_HUMAN
NCBI Description
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PHC2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Molecular Function: identical protein binding; protein binding
Biological Process: protein sumoylation
Research Articles on PHC2
Similar Products
Product Notes
The PHC2 phc2 (Catalog #AAA1271922) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagaatg agctgccagt cccacataca tctagcagtg cctgtgccac cagcagtacc agcggggcca gtagcagcag tggctgcaac aacagcagca gtggtggaag tggccgcccc accgggcccc agatttctgt gtacagtggt attccagacc ggcagaccgt gcaggtgatc cagcaggccc tgcacagaca gcccagcacg gccgctcagt acctgcagca gatgtacgcc gcccagcagc agcacctcat gctgcagacc gcggcgctcc agcagcagca cctcagcagc gcccagctcc agagcctggc agccgtacag caggcaagcc tggtatccaa tagacaagga agcacttcag gcagcaatgt gtctgcgcag gccccggccc agtcatcttc gatcaacctg gcagcctccc cagcagcagc ccagctcctc aaccgggccc agagtgtgaa ctctgcagca gcctcaggca tcgctcagca ggctgtgctc ttgggcaaca cgtcttcccc agccctgact gcaagccaag cacagatgta tctgagggca cagatggtac agaacttgac cctccgaaca cagcagacac cagcggcagc agcctcgggc cccaccccca ctcagcctgt cctgcccagc ttggccctga aacccacgcc gggcggtagc cagcctctgc ctaccccagc acagagcaga aatactgctc aggcttcccc cgcaggtgcc aagcctggca tagctgacag tgtgatggag ccacacaaga aaggagatgg caacagcagt gtgccaggga gcatggaagg ccgggctggg ctcagccgga cggttcctgc tgtggctgcc caccccctca ttgcaccagc ctatgctcag ctgcagccac accagctcct cccacagcca tcctcaaagc acctgcagcc ccaatttgtg atccagcagc agccacagcc acaacagcag cagccgccgc cccagcagtc acggcctgtg ctccaagctg agccccaccc ccagctcgcc tcagtctctc caagcgtggc cctccagccc agctcagagg cccatgccat gccactaggc ccggttacac ccgccctgcc actccagtgt cccactgcca acctgcacaa gcctggcggc agtcagcagt gtcaccctcc cacacctgat actgggcctc agaatggaca tcccgagggc gtgccccaca cccctcaacg caggttccag cacacttcag ctgtcatctt acaactgcag cctgcttcac cagtgcccca gcagtgtgtc cctgatgact ggaaagaaat ggcaccaggg gagaaaagtg tgcctgagac gcggtctggc ccatcaccac atcagcaggc tattgtcact gccatgcctg gtggcctgcc tgtacccacg agccctaaca tccagccgtc cccagctcac gagacagggc agggcattgt tcatgcactg accgacctca gcagccccgg catgacctca gggaacggaa actctgcctc cagcatcgcc ggcactgccc cccagaatgg tgagaataaa ccaccacagg ccattgtgaa accccaaatc ctgacgcatg ttatcgaagg gtttgtgatc caggaggggg cggagccttt cccggtggga cgctcgtccc tgctggtggg gaatctcaag aagaagtatg cacaggggtt cctgcctgag aaacttccac agcaggatca caccaccacc actgactcgg agatggagga gccctatctg caagaatcca aagaggaggg tgctcccctc aaactcaagt gtgagctctg tggccgggtg gactttgcct ataagttcaa gcgttccaag cgcttctgtt ccatggcttg tgcaaagagg tacaacgtgg gatgcaccaa acgggtggga cttttccact cagaccggag caagctgcag aaggcaggag ctgcgaccca caaccgccgt cgggccagca aagccagtct gccaccactt accaaggata ccaagaagca gccaacaggc actgtgcccc tttcggttac tgctgctttg cagctaacac acagccagga agactccagc cgttgctcag ataactcaag ctatgaggaa cccttgtcac ccatctcagc cagctcatct acttcccgcc ggcgacaagg ccagcgggac ctggagctcc ccgacatgca tatgcgggac ctggtgggca tgggacacca cttcctgcca agtgagccca ccaagtggaa tgtagaagac gtctacgaat tcatccgctc tctgccaggc tgccaggaga tagcagagga attccgtgcc caggaaatcg acgggcaagc cctgctgctg ctcaaggagg accacctgat gagcgccatg aacatcaagc tggggcccgc cctgaagatc tatgcccgca tcagcatgct caaggactcc tag. It is sometimes possible for the material contained within the vial of "PHC2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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