MGEA5 cdna clone
MGEA5 cDNA Clone
Gene Names
MGEA5; OGA; MEA5; NCOAT
Synonyms
MGEA5; MGEA5 cDNA Clone; MGEA5 cdna clone
Sequence
atggtgcagaaggagagtcaagcgacgttggaggagcgggagagcgagctcagctccaaccctgccgcctctgcgggggcatcgctggagccgccggcagctccggcacccggagaagacaaccccgccggggctgggggagcggcggtggccggggctgcaggaggggctcggcggttcctctgcggtgtggtggaaggattttatggaagaccttgggttatggaacagagaaaagaactctttagaaggctccagaaatgggaattaaatacatacttgtatgccccaaaagatgactacaaacataggatgttttggcgagagatgtattcagtggaggaagctgagcaacttatgactctcatctctgctgcacgagaatatgagatagagttcatctatgcgatctcacctggattggatatcactttttctaaccccaaggaagtatccacattgaaacgtaaattggaccaggtttctcagtttgggtgcagatcatttgctttgctttttgatgatatagaccataatatgtgtgcagcagacaaagaggtattcagttcttttgctcatgcccaagtctccatcacaaatgaaatctatcagtacctaggagagccagaaactttcctcttctgtcccacagaatactgtggcactttctgttatccaaatgtgtctcagtctccatatttaaggactgtgggtgaaaagcttctacctggaattgaagtgctttggacaggtcccaaagttgtttctaaagaaattccagtagagtccatcgaagaggtttctaagattattaagagagctccagtaatctgggataacattcatgctaatgattatgatcagaagagactgtttctgggcccgtacaaaggaagatccacagaactcatcccacggttaaaaggagtcctcactaatccaaattgtgaatttgaagccaactacgttgctatccacacccttgccacctggtacaaatcaaacatgaatggagtgagaaaagatgtagtgatgagtaggcaagttgcacacagtggagctaaagcaagtgtagttgatgggactcctttagttgcagcaccctctttaaatgccacaaccgtagtaacaacagtttatcaggagcccattatgagccagggagcagccttgagtggtgagcctactactctgaccaaggaagaagaaaagaaacagcctgatgaagaacccatggacatggtggtggaaaaacaagaagaaacggaccacaagaatgacaatcaaatactgagtgaaattgttgaagcgaaaatggcagaggaattgaaaccaatggacactgataaagagagcatagctgaatcaaaatccccagagatgtccatgcaagaagattgtattagtgacattgcccccatgcaaactgatgaacagacaaacaaggagcagtttgtgccaggtccaaatgaaaagcctttgtacactgcggaaccagtgaccctggaggatttgcagttacttgctgatctattctaccttccttacgagcatggacccaaaggagcacagatgttacgggaatttcaatggcttcgagcaaatagtagtgttgtcagtgtcaattgcaaaggaaaagactctaaaaaaattgaagaatggcggtcacgagcagccaagtttgaagagatgtgtggactagtgatgggaatgttcactcggctctccaattgtgccaacaggacaattctttatgacatgtactcctatgtttgggatatcaagagtataatgtctatggtgaagtcttttgtacagtggttagggtgtcgtagtcattcttcagcacaattcttaattggagaccaagaaccctgggcctttagaggtggtctagcaggagagttccagccacctccactgactcctacctccaaagtttatactatcagaccttattttcctaaggatgaggcatccgtgtacaagatttgcagagaaatgtatgacgatggagtgggtttaccctttcaaagtcagcctgatcttattggagacaagttagtaggagggctgctttccctcagcctggattactgctttgtcctagaagatgaagatggcatatgtggttatgccttgggcactgtagatgtgaccccctttattaaaaaatgtaaaatttcctggatccccttcatgcaggagaagtataccaagccaaatggtgacaaggaactctctgaggctgagaaaataatgttgagtttccatgaagaacaggaagtactgccagaaactttccttgctaatttcccttctctgataaagatggacattcacaaaaaagtaactgacccaagtgtggccaaaagcatgatggcttgcctcctgtcttcactgaaggctaatggctcccggggagctttctgtgaagtgagaccagatgataaaagaattctggaattttacagcaagttaggatgttttgaaattgcaaaaatggaaggatttccaaaggatgtggttatacttggtcggagcctgtga
Sequence Length
2550
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
96,932 Da
NCBI Official Full Name
Homo sapiens meningioma expressed antigen 5 (hyaluronidase), mRNA
NCBI Official Synonym Full Names
meningioma expressed antigen 5 (hyaluronidase)
NCBI Official Symbol
MGEA5
NCBI Official Synonym Symbols
OGA; MEA5; NCOAT
NCBI Protein Information
protein O-GlcNAcase
UniProt Protein Name
Protein O-GlcNAcase
Protein Family
UniProt Gene Name
MGEA5
UniProt Synonym Gene Names
HEXC; KIAA0679; MEA5; NCOAT
UniProt Entry Name
OGA_HUMAN
NCBI Description
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Uniprot Description
OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.52; EC 3.2.1.169; Hydrolase; Acetyltransferase
Chromosomal Location of Human Ortholog: 10q24.1-q24.3
Cellular Component: cytosol; membrane
Molecular Function: beta-N-acetylglucosaminidase activity; hyalurononglucosaminidase activity
Biological Process: glycoprotein catabolic process; N-acetylglucosamine metabolic process; protein deglycosylation
Research Articles on MGEA5
Similar Products
Product Notes
The MGEA5 mgea5 (Catalog #AAA1271856) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtgcaga aggagagtca agcgacgttg gaggagcggg agagcgagct cagctccaac cctgccgcct ctgcgggggc atcgctggag ccgccggcag ctccggcacc cggagaagac aaccccgccg gggctggggg agcggcggtg gccggggctg caggaggggc tcggcggttc ctctgcggtg tggtggaagg attttatgga agaccttggg ttatggaaca gagaaaagaa ctctttagaa ggctccagaa atgggaatta aatacatact tgtatgcccc aaaagatgac tacaaacata ggatgttttg gcgagagatg tattcagtgg aggaagctga gcaacttatg actctcatct ctgctgcacg agaatatgag atagagttca tctatgcgat ctcacctgga ttggatatca ctttttctaa ccccaaggaa gtatccacat tgaaacgtaa attggaccag gtttctcagt ttgggtgcag atcatttgct ttgctttttg atgatataga ccataatatg tgtgcagcag acaaagaggt attcagttct tttgctcatg cccaagtctc catcacaaat gaaatctatc agtacctagg agagccagaa actttcctct tctgtcccac agaatactgt ggcactttct gttatccaaa tgtgtctcag tctccatatt taaggactgt gggtgaaaag cttctacctg gaattgaagt gctttggaca ggtcccaaag ttgtttctaa agaaattcca gtagagtcca tcgaagaggt ttctaagatt attaagagag ctccagtaat ctgggataac attcatgcta atgattatga tcagaagaga ctgtttctgg gcccgtacaa aggaagatcc acagaactca tcccacggtt aaaaggagtc ctcactaatc caaattgtga atttgaagcc aactacgttg ctatccacac ccttgccacc tggtacaaat caaacatgaa tggagtgaga aaagatgtag tgatgagtag gcaagttgca cacagtggag ctaaagcaag tgtagttgat gggactcctt tagttgcagc accctcttta aatgccacaa ccgtagtaac aacagtttat caggagccca ttatgagcca gggagcagcc ttgagtggtg agcctactac tctgaccaag gaagaagaaa agaaacagcc tgatgaagaa cccatggaca tggtggtgga aaaacaagaa gaaacggacc acaagaatga caatcaaata ctgagtgaaa ttgttgaagc gaaaatggca gaggaattga aaccaatgga cactgataaa gagagcatag ctgaatcaaa atccccagag atgtccatgc aagaagattg tattagtgac attgccccca tgcaaactga tgaacagaca aacaaggagc agtttgtgcc aggtccaaat gaaaagcctt tgtacactgc ggaaccagtg accctggagg atttgcagtt acttgctgat ctattctacc ttccttacga gcatggaccc aaaggagcac agatgttacg ggaatttcaa tggcttcgag caaatagtag tgttgtcagt gtcaattgca aaggaaaaga ctctaaaaaa attgaagaat ggcggtcacg agcagccaag tttgaagaga tgtgtggact agtgatggga atgttcactc ggctctccaa ttgtgccaac aggacaattc tttatgacat gtactcctat gtttgggata tcaagagtat aatgtctatg gtgaagtctt ttgtacagtg gttagggtgt cgtagtcatt cttcagcaca attcttaatt ggagaccaag aaccctgggc ctttagaggt ggtctagcag gagagttcca gccacctcca ctgactccta cctccaaagt ttatactatc agaccttatt ttcctaagga tgaggcatcc gtgtacaaga tttgcagaga aatgtatgac gatggagtgg gtttaccctt tcaaagtcag cctgatctta ttggagacaa gttagtagga gggctgcttt ccctcagcct ggattactgc tttgtcctag aagatgaaga tggcatatgt ggttatgcct tgggcactgt agatgtgacc ccctttatta aaaaatgtaa aatttcctgg atccccttca tgcaggagaa gtataccaag ccaaatggtg acaaggaact ctctgaggct gagaaaataa tgttgagttt ccatgaagaa caggaagtac tgccagaaac tttccttgct aatttccctt ctctgataaa gatggacatt cacaaaaaag taactgaccc aagtgtggcc aaaagcatga tggcttgcct cctgtcttca ctgaaggcta atggctcccg gggagctttc tgtgaagtga gaccagatga taaaagaatt ctggaatttt acagcaagtt aggatgtttt gaaattgcaa aaatggaagg atttccaaag gatgtggtta tacttggtcg gagcctgtga. It is sometimes possible for the material contained within the vial of "MGEA5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
