TSPAN12 cdna clone
TSPAN12 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Uniprot Description
TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q31.31
Cellular Component: integral to membrane; integral to plasma membrane; membrane
Molecular Function: protein binding; Wnt receptor activity
Biological Process: cell surface receptor linked signal transduction; regulation of angiogenesis
Disease: Exudative Vitreoretinopathy 5
Research Articles on TSPAN12
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Product Notes
The TSPAN12 tspan12 (Catalog #AAA1271839) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccagag aagattccgt gaagtgtctg cgctgcctgc tctacgccct caatctgctc ttttggttaa tgtccatcag tgtgttggca gtttctgctt ggatgaggga ctacctaaat aatgttctca ctttaactgc agaaacgagg gtagaggaag cagtcatttc gacttacttt cctgtggttc atccggtcat gattgctgtt tgctgtttcc ttatcattgt ggggatgtta ggatattgtg gaacggtgaa aagaaatctg ttgcttcttg catggtactt tggaagtttg cttgtcattt tctgtgtaga actggcttgt ggcgtttgga catatgaaca ggaacttatg gttccagtac aatggtcaga tatggtcact ttgaaagcca ggatgacaaa ttatggatta cctagatatc ggtggcttac tcatgcttgg aatttttttc agagagagtt taagtgctgt ggagtagtat atttcactga ctggttggaa atgacagaga tggactggcc cccagattcc tgctgtgtta gagaattccc aggatgttcc aaacaggccc accaggaaga tctcagtgac ctttatcaag agggttgtgg gaagaaaatg tattcctttt tgagaggaac caaacaactg caggtgctga ggtttctggg aatctccatt ggggtgacac aaatcctggc catgattctc accattactc tgctctgggc tctgtattat gatagaaggg agcctgggac agaccaaatg atgtccttga agaatgacaa ctctcagcac ctgtcatgtc cctcagtaga actgttgaaa ccaagcctgt caagaatctt tgaacacaca tccatggcaa acagctttaa tacacacttt gagatggagg agttataa. It is sometimes possible for the material contained within the vial of "TSPAN12, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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