PRDM5 cdna clone
PRDM5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
PRDM5: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase, protein lysine, predicted; Transcription factor; DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 4q25-q26
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: histone deacetylation; histone H3-K9 methylation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Brittle Cornea Syndrome 2
Research Articles on PRDM5
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Product Notes
The PRDM5 prdm5 (Catalog #AAA1271675) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTGGGCA TGTACGTGCC GGACAGGTTC TCCCTGAAGT CCTCCCGGGT TCAGGACGGC ATGGGGCTCT ACACGGCCCG CAGAGTGCGA AAGGGTGAAA AGTTCGGACC CTTTGCTGGA GAGAAGAGAA TGCCTGAAGA CTTGGATGAA AATATGGATT ACAGGTTGAT GTGGGAGGTT CGTGGGAGTA AGGGAGAAGT TTTGTACATT TTGGATGCTA CCAACCCACG GCACTCCAAC TGGCTTCGCT TCGTTCATGA GGCACCATCT CAGGAGCAGA AGAACTTGGC TGCCATTCAA GAAGGAGAAA ACATTTTCTA TTTGGCAGTT GAAGATATAG AAACAGACAC GGAGCTTCTG ATTGGCTACC TGGATAGTGA CATGGAGGCT GAGGAGGAAG AACAGCAAAT TATGACAGTC ATCAAAGAAG GGGAAGTTGA AAATTCTAGA AGACAATCAA CAGCGGGCAG AAAAGATCGC CTTGGCTGTA AAGAGGACTA TGCTTGTCCT CAATGTGAAT CGAGTTTTAC CAGTGAGGAT ATTCTTGCTG AGCATCTCCA GACATTGCAC CAGAAACCCA CAGAGGAGAA AGAATTTAAG TGCAAGAACT GTGGGAAGAA ATTCCCAGTT AAGCAGGCTT TGCAAAGACA TTTTGAGCAG CACCAGGAGA CTTGCCGGGG GGATGCCAGG TTTGTGTGCA AGGCTGACAG CTGTGGAAAG AGGCTGAAGA GCAAGGATGC CCTGAAAAGA CACCAGGAAA ATGTCCACAC TGGAGATCCT AAGAAAAAGC TTATATGTTC AGTGTGCAAT AAAAAGTGTT CTTCAGCATC AAGCCTACAG GAACATAGAA AGATTCATGA GATATTTGAT TGTCAAGAAT GTATGAAGAA ATTTATTTCA GCTAATCAGC TAAAACGTCA TATGATCACC CACTCAGAAA AACGACCCTA TAATTGCGAG ATTTGTAATA AGTCTTTCAA GAGGCTTGAT CAAGTGGGTG CTCACAAAGT AATACACAGC GAAGACAAAC CTTACAAATG CAAACTTTGT GGAAAGGGAT TTGCCCACAG AAATGTTTAC AAGAATCATA AGAAGACCCA CTCTGAGGAG AGACCGTTCC AATGTGAAGA ATGTAAAGCT CTGTTCCGGA CCCCATTTTC TTTACAGAGA CACCTGCTAA TACATAACAG TGAGAGGACT TTCAAGTGCC ATCACTGCGA TGCTACCTTT AAGAGGAAGG ATACATTAAA TGTTCATGTC CAGGTGGTTC ATGAAAGACA CAAGAAGTAT AGGTGTGAGC TATGTAATAA GGCCTTTGTT ACACCTTCAG TGCTTAGAAG TCATAAGAAA ACACATACAG GAGAAAAGGA GAAAATCTGT CCATATTGTG GCCAGAAATT TGCCAGCAGT GGTACACTCA GAGTTCATAT CCGGAGCCAC ACAGGTGAGC GTCCCTATCA ATGTCCTTAC TGTGAAAAAG GATTCAGTAA AAATGATGGA CTGAAGATGC ACATTCGTAC TCACACCAGG GAGAAGCCGT ACAAGTGCTC AGAGTGCAGC AAGGCCTTCA GCCAGAAGCG AGGCCTGGAT GAGCACAAGA GGACGCACAC TGGAGAAAAG CCTTTTCAGT GTGATGTTTG TGATTTGGCT TTTAGCCTGA AGAAAATGCT GATTCGACAC AAGATGACTC ATAATCCCAA TCGTCCCCTG GCAGAATGCC AGTTTTGCCA TAAGAAGTTT ACAAGGAATG ACTACCTCAA AGTGCACATG GACAATATCC ATGGTGTAGC TGACAGCTAA. It is sometimes possible for the material contained within the vial of "PRDM5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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