TMC6 cdna clone
TMC6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Uniprot Description
TMC6: Defects in TMC6 are a cause of epidermodysplasia verruciformis (EV). It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Belongs to the TMC family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytoplasm; endoplasmic reticulum; Golgi apparatus; nuclear membrane
Molecular Function: protein binding
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC6
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Product Notes
The TMC6 tmc6 (Catalog #AAA1271464) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctcact ctttcgggga gagctaccgg gtgggcagca cctctggcat ccacgccatc accgtcttct gctcctggga ctacaaggtg acgcagaagc gggcctcccg cctccagcag gacaatattc gcacccggct gaaggagctg ctggccgagt ggcagctgcg gcacagcccc aggagcgtgt gcgggaggct gcggcaggcg gctgtgctgg ggcttgtgtg gctgctgtgt ctggggaccg cgctgggctg cgccgtggcc gtccacgtct tctcggagtt catgatccag agtccagagg ctgctggcca ggaggctgtg ctgctggtcc tgcccctggt ggttggcctc ctcaacctgg gggcccccta cctgtgccgt gtcctggccg ccctggagcc gcatgactcc ccggtactgg aggtgtacgt ggccatctgc aggaacctca tcctcaagct ggccatcctg gggacactgt gctaccactg gctgggccgc agggtgggcg tcctgcaggg ccagtgctgg gaggattttg tgggccagga gctgtaccgg ttcctggtga tggacttcgt cctcatgttg ctggacacgc tttttgggga actggtgtgg aggattatct ccgagaagaa gctgaagagg aggcggaagc cggagtttga cattgcccgg aatgtcctgg agctgattta tgggcagact ctgacctggc tgggggtgct cttctcgccc ctcctccccg ccgtgcagat catcaagctg ctgctcgtct tctatgtcaa gaagaccagc cttctggcca actgccaggc gccgcgccgg ccctggctgg cctcacacat gagcaccgtc ttcctcacgc tgctctgctt ccccgccttc ctgggcgccg ctgtcttcct ctgctacgcc gtctggcagg tgaagccctc gagcacctgc ggccccttcc ggaccctgga caccatgtac gaggccggca gggtgtgggt gcgccacctg gaggcggcag gccccagggt ctcctggctg ccctgggtgc accggtacct gatggaaaac accttctttg tcttcctggt gtcagccctg ctgctggccg tgatctacct caacatccag gtggtgcggg gccagcgcaa ggtcatctgc ctgctcaagg agcagatcag caatgagggt gaggacaaaa tcttcttaat caacaagctt cactccatct acgagaggaa ggagagggag gagaggagca gggttgggac aaccgaggag gctgcggcac cccctgccct gctcacagat gaacaggatg cctag. It is sometimes possible for the material contained within the vial of "TMC6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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