TGFA cdna clone
TGFA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
TGFalpha: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Ligand, receptor tyrosine kinase; Cell cycle regulation
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: basolateral plasma membrane; cell surface; cytoplasmic vesicle; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm
Molecular Function: epidermal growth factor receptor binding; growth factor activity; protein binding
Biological Process: activation of MAPK activity; cell proliferation; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of mitosis
Research Articles on TGFA
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Product Notes
The TGFA tgfa (Catalog #AAA1271401) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtcccct cggctggaca gctcgccctg ttcgctctgg gtattgtgtt ggctgcgtgc caggccttgg agaacagcac gtccccgctg agtgacccgc ccgtggctgc agcagtggtg tcccatttta atgactgccc agattcccac actcagttct gcttccatgg aacctgcagg tttttggtgc aggaggacaa gccagcatgt gtctgccatt ctgggtacgt tggtgcacgc tgtgagcatg cggacctcct ggccgtggtg gctgccagcc agaagaagca ggccatcacc gccttggtgg tggtctccat cgtggccctg gctgtcctta tcatcacatg tgtgctgata cactgctgcc aggtccgaaa acactgtgag tggtgccggg ccctcatctg ccggcacgag aagcccagcg ccctcctgaa gggaagaacc gcttgctgcc actcagaaac agtggtctga. It is sometimes possible for the material contained within the vial of "TGFA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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