KIRREL cdna clone

KIRREL cDNA Clone

Gene Names

KIRREL; NEPH1

Synonyms

KIRREL; KIRREL cDNA Clone; KIRREL cdna clone

Ordering
Cat. Num. AAA1270529 For Research Use Only!

Sequence

ATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTGTAG

Sequence Length

2274

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #

80475806

NCBI GeneID

55243

Molecular Weight

72,360 Da

NCBI Official Full Name

Homo sapiens kin of IRRE like (Drosophila), mRNA

NCBI Official Synonym Full Names

kin of IRRE like (Drosophila)

NCBI Official Symbol

KIRREL

NCBI Official Synonym Symbols

NEPH1

NCBI Protein Information

kin of IRRE-like protein 1

UniProt Protein Name

Kin of IRRE-like protein 1

Protein Family

Kin of IRRE-like protein

UniProt Gene Name

KIRREL

UniProt Synonym Gene Names

KIRREL1; NEPH1

UniProt Entry Name

KIRR1_HUMAN

NCBI Description

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]

Uniprot Description

KIRREL: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. Belongs to the immunoglobulin superfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: intercellular junction; perinuclear region of cytoplasm; plasma membrane

Molecular Function: myosin binding; protein binding

Research Articles on KIRREL

1. maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN-induced injury and PAN-induced albumin leakage

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Product Notes

The KIRREL kirrel (Catalog #AAA1270529) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTGAGCC TCCTCGTCTG GATCCTCACT CTCTCCGATA CTTTCTCCCA AGGGACCCAG ACCCGCTTCA GCCAGGAGCC AGCTGACCAG ACGGTGGTGG CTGGACAGCG GGCCGTGCTC CCCTGTGTGC TGCTCAACTA CTCTGGAATT GTGCAATGGA CCAAGGACGG GCTGGCCCTG GGCATGGGCC AGGGCCTCAA AGCCTGGCCA CGGTACCGGG TTGTGGGCTC CGCAGACGCT GGGCAGTACA ACCTGGAGAT CACAGATGCT GAGCTCTCTG ACGACGCCTC TTACGAGTGC CAGGCCACGG AGGCCGCCCT GCGCTCTCGG CGGGCCAAAC TCACCGTGCT CATCCCCCCA GAGGACACCA GGATTGACGG AGGCCCTGTG ATTCTACTGC AGGCAGGCAC CCCCCACAAC CTCACATGCC GGGCCTTCAA TGCGAAGCCT GCTGCCACCA TCATCTGGTT CCGGGACGGG ACGCAGCAGG AGGGCGCTGT GGCCAGCACG GAATTGCTGA AGGATGGGAA GAGGGAGACC ACCGTGAGCC AACTGCTTAT TAACCCCACG GACCTGGACA TAGGGCGTGT CTTCACTTGC CGAAGCATGA ACGAAGCCAT CCCTAGTGGC AAGGAGACTT CCATCGAGCT GGATGTGCAC CACCCTCCTA CAGTGACCCT GTCCATTGAG CCACAGACGG TGCAGGAGGG TGAGCGTGTT GTCTTTACCT GCCAGGCCAC AGCCAACCCC GAGATCTTGG GCTACAGGTG GGCCAAAGGG GGTTTCTTGA TTGAAGACGC CCACGAGAGT CGCTATGAGA CAAATGTGGA TTATTCCTTT TTCACGGAGC CTGTGTCTTG TGAGGTTCAC AACAAAGTGG GAAGCACCAA TGTCAGCACT TTAGTAAATG TCCACTTTGC TCCCCGGATT GTAGTTGACC CCAAACCCAC AACCACAGAC ATTGGCTCTG ATGTGACCCT TACCTGTGTC TGGGTTGGGA ATCCCCCCCT CACTCTCACC TGGACCAAAA AGGACTCAAA TATGGTCCTG AGTAACAGCA ACCAGCTGCT GCTGAAGTCG GTGACTCAGG CAGACGCTGG CACCTACACC TGCCGGGCCA TCGTGCCTCG AATCGGAGTG GCTGAGCGGG AGGTGCCGCT CTATGTGAAC GGGCCCCCCA TCATCTCCAG TGAGGCAGTG CAGTATGCTG TGAGGGGTGA CGGTGGCAAG GTGGAGTGTT TCATTGGGAG CACACCACCC CCAGACCGCA TAGCATGGGC CTGGAAGGAG AACTTCTTGG AGGTGGGGAC CCTGGAACGC TATACAGTGG AGAGGACCAA CTCAGGCAGT GGGGTGCTAT CCACGCTCAC CATCAACAAT GTCATGGAGG CCGACTTTCA GACTCACTAC AACTGCACCG CCTGGAACAG CTTCGGGCCA GGCACAGCCA TCATCCAGCT GGAAGAGCGA GAGGTGTTAC CTGTGGGCAT CATAGCTGGG GCCACCATCG GCGCGAGCAT CCTGCTCATC TTCTTCTTCA TCGCCTTGGT ATTCTTCCTC TACCGGCGCC GCAAAGGCAG TCGCAAAGAC GTGACCCTGA GGAAGCTGGA TATCAAGGTG GAGACAGTGA ACCGAGAGCC ACTTACGATG CATTCTGACC GGGAGGATGA CACCGCCAGC GTCTCCACAG CAACCCGGGT CATGAAGGCC ATCTACTCGT CGTTTAAGGA TGATGTGGAT CTGAAGCAGG ACCTGCGCTG CGACACCATC GACACCCGGG AGGAGTATGA GATGAAGGAC CCCACCAATG GCTACTACAA CGTGCGTGCC CATGAAGACC GCCCGTCTTC CAGGGCAGTG CTCTATGCTG ACTACCGTGC CCCTGGCCCT GCCCGCTTCG ACGGCCGCCC CTCATCCCGT CTCTCCCACT CCAGCGGCTA TGCCCAGCTC AACACCTATA GCCGGGGCCC TGCCTCTGAC TATGGCCCTG AGCCCACACC CCCTGGCCCT GCTGCCCCAG CTGGCACTGA CACAACCAGC CAGCTGTCCT ACGAGAACTA TGAGAAGTTC AACTCCCATC CCTTCCCTGG GGCAGCTGGG TACCCCACCT ACCGACTGGG CTACCCCCAG GCCCCACCCT CTGGCCTGGA GCGGACCCCA TATGAGGCGT ATGACCCCAT TGGCAAGTAC GCCACAGCCA CTCGATTCTC CTACACCTCC CAGCACTCGG ACTACGGCCA GCGATTCCAG CAGCGCATGC AGACTCACGT GTAG. It is sometimes possible for the material contained within the vial of "KIRREL, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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KIRREL cdna clone