MBNL2 cdna clone
MBNL2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Uniprot Description
MBNL2: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). Belongs to the muscleblind family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 13q32.1
Biological Process: regulation of RNA splicing
Research Articles on MBNL2
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Product Notes
The MBNL2 mbnl2 (Catalog #AAA1270516) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTTTGA ACGTTGCCCC AGTCAGAGAT ACAAAATGGC TGACATTAGA AGTCTGCAGA CAGTTTCAAA GAGGAACATG CTCACGCTCT GATGAAGAAT GCAAATTTGC TCATCCCCCC AAAAGTTGTC AGGTTGAAAA TGGAAGAGTA ATTGCCTGCT TTGATTCCCT AAAGGGCCGT TGTTCGAGAG AGAACTGCAA GTATCTTCAC CCTCCGACAC ACTTAAAAAC TCAACTAGAA ATTAATGGAA GGAACAATTT GATTCAGCAA AAAACTGCAG CAGCAATGCT TGCCCAGCAG ATGCAATTTA TGTTTCCAGG AACACCACTT CATCCAGTGC CCACTTTCCC TGTAGGTCCC GCGATAGGGA CAAATACGGC TATTAGCTTT GCTCCTTACC TAGCACCTGT AACCCCTGGA GTTGGGTTGG TCCCAACGGA AATTCTGCCC ACCACGCCTG TTATTGTTCC CGGAAGTCCA CCGGTCACTG TCCCGGGCTC AACTGCAACT CAGAAACTTC TCAGGACTGA CAAACTGGAG GTATGCAGGG AGTTCCAGCG AGGAAACTGT GCCCGGGGAG AGACCGACTG CCGCTTTGCA CACCCCGCAG ACAGCACCAT GATCGACACA AGTGACAACA CCGTAACCGT TTGTATGGAT TACATAAAGG GGCGTTGCAT GAGGGAGAAA TGCAAATATT TTCACCCTCC TGCACACTTG CAGGCCAAAA TCAAAGCTGC GCAGCACCAA GCCAACCAAG CTGCGGTGGC CGCCCAGGCA GCCGCGGCCG CGGCCACAGT CATGGCCTTT CCCCCTGGTG CTCTTCATCC TTTACCAAAG AGACAAGCAC TTGAAAAAAG CAATGGTACC AGCGCGGTCT TTAACCCCAG CGTCTTGCAC TACCAGCAGG CTCTCACCAG CGCACAGTTG CAGCAACACG CCGCGTTCAT TCCAACAGGG TCAGTTTTGT GCATGACACC CGCTACCAGT ATTGTACCCA TGATGCACAG CGCTACGTCC GCCACTGTCT CTGCAGCAAC AACTCCTGCA ACAAGTGTCC CCTTCGCAGC AACAGCCACA GCCAATCAGA TAATTCTGAA ATAA. It is sometimes possible for the material contained within the vial of "MBNL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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