SMC3 cdna clone
SMC3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Uniprot Description
SMC3: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Interacts with MXI1, MXD3 and MXD4. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and in chromosome movement. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation. Belongs to the SMC family. SMC3 subfamily.
Protein type: DNA repair, damage; Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: chromatin; chromosome; chromosome, pericentric region; cytoplasm; cytosol; nuclear matrix; nucleoplasm; nucleus; spindle pole
Molecular Function: dynein binding; protein binding; protein heterodimerization activity
Biological Process: meiosis; mitosis; mitotic spindle organization and biogenesis; negative regulation of DNA endoreduplication; protein sumoylation; regulation of DNA replication; signal transduction; sister chromatid cohesion
Disease: Cornelia De Lange Syndrome 3
Research Articles on SMC3
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Product Notes
The SMC3 smc3 (Catalog #AAA1270475) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtacataa agcaggtgat tatccagggt tttcgaagtt acagagatca aacaattgta gatcccttca gttcaaaaca taatgtgatt gtgggcagaa atggatctgg aaaaagtaac cttttttatg caattcagtt tgttctcagt gatgagttta gtcatcttcg tccagaacag cggttggctt tattgcatga aggtactggt cctcgtgtta tttctgcttt tgtggagatt atttttgata attcagacaa ccggttacca atcgataaag aggaagtttc acttcgaaga gttattggtg ccaaaaagga tcagtatttc ttagacaaga agatggtcac gaaaaatgat gtgatgaacc tccttgaaag cgctggtttt tctcgaagca atccttatta tattgttaaa caaggaaaga tcaaccagat ggcaacagca ccagattctc agagattaaa gctattaaga gaagtagctg gtactagagt gtatgacgaa cgaaaggaag aaagcatctc cttaatgaaa gaaacagagg gcaaacggga aaaaatcaat gagttgttaa aatacattga agagagatta catactctag aggaagaaaa ggaagaacta gctcagtatc agaagtggga taaaatgaga cgagccctgg aatataccat ttacaatcag gaacttaacg agactcgtgc caaacttgat gagctttctg ctaagcgaga gactagtgga gaaaaatcca gacaattaag agatgctcag caggatgcaa gagataaaat ggaggatatc gaacgccaag ttagagaatt gaaaacaaaa atttcagcta tgaaagaaga aaaagaacag cttagtgctg aaagacaaga gcagattaag cagaggacta agttggagct taaagccaag gatttacaag atgaactagc aggcaatagt gaacaaagga aacgtttatt aaaagagagg cagaagctgc ttgaaaaaat agaagaaaag cagaaagaac tggcagaaac agaacccaaa ttcaacagtg tgaaagagaa agaagaacga ggaattgcta gattggctca agctacccag gaaagaacgg atctttatgc aaagcagggt cgaggaagcc agtttacatc aaaagaagaa agggataagt ggattaaaaa ggaactcaag tctttagatc aggctattaa tgacaagaaa agacagattg ctgctataca taaggatttg gaagacactg aagcaaataa agagaaaaat ctggagcagt ataataaact ggaccaggat cttaatgaag tcaaagctcg agtagaagaa ctggacagaa aatattacga agtaaaaaat aagaaagatg aactacaaag tgaaagaaac tacttgtgga gagaagagaa tgcagaacag caagcacttg ctgctaaaag agaagatctt gaaaagaagc aacaacttct tagagcagca acaggaaagg ccattttaaa tggaatagac agcataaaca aagtgctaga ccacttccgt cgaaaaggaa taaaccagca tgttcaaaat ggctatcatg gtattgtaat gaataacttt gaatgtgaac cagctttcta cacatgcgtg gaagtcactg ctggaaacag gttattttat cacattgttg attcagatga agtcagcacg aagattttaa tggagtttaa taaaatgaat cttcctggag aggttacttt tctgcctctt aacaagttag atgtcaggga tacagcctat cctgaaacca atgatgctat tcctatgatc agcaaactga ggtacaatcc cagatttgac aaagctttca aacatgtgtt tggaaagact cttatttgtc gtagcatgga agtttcaacc cagctggccc gtgctttcac tatggactgt attactttgg aaggtgacca agtcagccat cggggtgctc taactggggg ttattatgac acaaggaagt ctcgacttga attgcaaaaa gatgttagaa aagcagaaga agaactaggt gaacttgaag caaagctcaa tgaaaacctg cgcagaaata ttgaaaggat taataatgaa attgatcagt tgatgaacca aatgcaacag atcgagaccc agcaaaggaa atttaaagca tctagagata gcatattatc agaaatgaag atgctaaaag agaagaggca gcagtcagag aaaaccttca tgcctaagca acgtagctta cagagtttgg aggcaagctt gcatgctatg gagtctacca gagagtcatt gaaagcagaa ctgggaactg atttgctttc tcaactgagt ttggaagatc agaagagagt agatgcactg aatgatgaga ttcgtcaact tcagcaggaa aacagacagt tgctaaatga aagaattaaa ttagaaggta ttattactcg agtagagact tatctcaatg agaatctgag aaaacgcttg gaccaagtag aacaggaact taatgagctg agagagacag aagggggtac tgttctcaca gccacaacat cagaacttga agccatcaat aaaagagtaa aagacactat ggcacgatca gaagatttgg acaattccat tgataaaaca gaagctggaa ttaaggagct tcagaagagt atggagcgct ggaaaaatat ggaaaaagaa catatggatg ctataaatca tgatactaaa gaactggaaa agatgacaaa tcggcaaggc atgctattga agaagaaaga agagtgtatg aagaaaattc gagaacttgg atcacttccc caggaagcat ttgaaaagta ccagacactg agcctcaaac agttgtttcg aaaacttgag cagtgcaaca cagaattaaa gaagtacagc catgttaaca aaaaggcttt ggatcagttt gtaaatttct ccgagcagaa agaaaagtta ataaagcgtc aagaagagtt agataggggt tacaaatcga tcatggaact gatgaatgta cttgaacttc ggaaatatga agctattcag ttaactttca aacaggtatc taagaacttc agtgaagtat tccagaagtt agtacctggt ggcaaagcta ctttggtgat gaagaaagga gatgtggagg gcagtcagtc tcaagatgaa ggagaaggga gtggtgagag tgagaggggt tctggctcac aaagcagtgt cccatcagtt gaccagttta ctggagttgg aattagggtg tcatttacag gaaaacaagg tgaaatgaga gaaatgcaac agctttcagg tggacagaaa tccttggtag cccttgctct gatttttgcc attcagaaat gtgacccggc tccattttac ttgtttgatg aaattgacca ggctctggat gctcagcaca gaaaggctgt gtcagatatg attatggaac ttgctgtaca tgctcagttt attacaacta cttttaggcc tgaactgctt gagtcagctg acaaattcta tggtgtaaag ttcagaaata aggttagtca tattgatgtg atcacagcag agatggccaa agactttgta gaagatgata ccacacatgg ttaa. It is sometimes possible for the material contained within the vial of "SMC3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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