NLRP2 cdna clone
NLRP2 cDNA Clone
Gene Names
NLRP2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9
Synonyms
NLRP2; NLRP2 cDNA Clone; NLRP2 cdna clone
Sequence
atggtgtcttcggcgcagatgggcttcaacctgcaggctctcctggagcagctcagccaggatgagttgagcaagttcaagtatctgatcacgaccttctccctggcacacgagctccagaagatcccccacaaggaggtagacaaggctgatgggaagcaactggtagaagtcctcaccacccattgtgacagctactgggtggagatggcgagccttcaggtctttgaaaagatgcaccgaatggatctgtctgagagagcaaaggatgaagtcagagaagcagctttgaaatcctttaataaaaggaaacctctatcattagggataacacggaaagaacgaccacctctagacgtggacgaaatgctggagcgcttcaaaacagaagcacaagcgtttacagaaacgaaaggaaatgtcatctgcctgggtaaagaagtctttaaaggaaaaaagccagacaaagacaataggtgcaggtatatattgaagacgaagttccgggagatgtggaagagctggcctggagatagcaaagaggtccaggttatggctgagagatacaagatgctgatcccattcagcaaccccagggtgcttcccgggcccttctcatacacggtggtgctgtatggtcctgcaggccttgggaaaaccacgctggcccagaaactaatgctagactgggcagaggacaacctcatccacaaattcaaatatgcgttctacctcagctgcagggagctcagccgcctgggcccgtgcagttttgcagagctggtcttcagggactggcctgaattgcaggatgacattccacacatcctagcccaagcacggaaaatcttgttcgtgattgacggctttgatgagctgggagccgcacctggggcgctgatcgaggacatctgcggggactgggagaagaagaagccggtgcccgtcctcctggggagtttgctgaacagggtgatgttacccaaggccgccctgctggtcaccacgcggcccagggccctgagggacctccggatcctggcggaggagccgatctacataagggtggagggcttcctggaggaggacaggagggcctatttcctgagacactttggagacgaggaccaagccatgcgtgcctttgagctaatgaggagcaacgcggccctgttccagctgggctcggcccccgcggtgtgctggatcgtgtgcacgactctgaagctgcagatggagaagggggaggacccggtccccacctgcctcacccgcacggggctgttcctgcgtttcctctgcagccggttcccgcagggcgcacagctgcggggcgcgctgcggacgctgagcctcctggccgcgcagggcctgtgggcgcagacgtccgtgcttcaccgagaggatctggaaaggctcggggtgcaggagtccgacctccgtctgttcctggacggagacatcctccgccaggacagagtctccaaaggctgctactccttcatccacctcagcttccagcagtttctcactgccctgttctacaccctggagaaggaggaggaagaggatagggacggccacacctgggacattggggacgtacagaagctgctttccggagtagaaagactcaggaaccccgacctgatccaagcaggctactactcctttggcctcgctaacgagaagagagccaaggagttggaggccacttttggctgccggatgtcaccggacatcaaacaggaattgctgcgatgcgacataagttgtaagggtggacattcaacggtgacagacctgcaggagctcctcggctgtctgtacgagtctcaggaggaggagctggtgaaggaggtgatggctcagttcaaagaaatatccctgcacttaaatgcagtagacgttgtgccatcttcattctgcgtcaagcactgtcgaaacctgcagaaaatgtcactgcaggtaataaaggagaatctcccggagaatgtcactgcgtctgaatcagacgccgaggttgagagatcccaggatgatcagcacatgcttcctttctggacggacctttgttccatatttggatcaaataaggatctgatgggtctagcaatcaatgatagctttctcagtgcctccctagtaaggatcctgtgtgaacaaatagcctctgacacctgtcatctccagagagtggtgttcaaaaacatttccccagctgatgctcatcggaacctctgcctagctcttcgaggtcacaagactgtaacgtatctgacccttcaaggcaatgaccaggatgatatgtttcccgcattgtgtgaggtcttgagacatccagaatgtaacctgcgatatctcgggttggtgtcttgttccgctaccactcagcagtgggctgatctctccttggcccttgaagtcaaccagtccctgacgtgcgtaaacctctccgacaatgagcttctggatgagggtgctaagttgctgtacacaactttgagacaccccaagtgctttctgcagaggttgtcgtaa
Sequence Length
2541
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
117,883 Da
NCBI Official Full Name
Homo sapiens NLR family, pyrin domain containing 2, mRNA
NCBI Official Synonym Full Names
NLR family pyrin domain containing 2
NCBI Official Symbol
NLRP2
NCBI Official Synonym Symbols
NBS1; PAN1; NALP2; PYPAF2; CLR19.9
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 2
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 2
Protein Family
UniProt Gene Name
NLRP2
UniProt Synonym Gene Names
NALP2; NBS1; PAN1; PYPAF2
UniProt Entry Name
NALP2_HUMAN
NCBI Description
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Uniprot Description
NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nuclear chromosome, telomeric region
Molecular Function: protein binding; Pyrin domain binding
Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion
Research Articles on NLRP2
Similar Products
Product Notes
The NLRP2 nlrp2 (Catalog #AAA1270143) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtgtctt cggcgcagat gggcttcaac ctgcaggctc tcctggagca gctcagccag gatgagttga gcaagttcaa gtatctgatc acgaccttct ccctggcaca cgagctccag aagatccccc acaaggaggt agacaaggct gatgggaagc aactggtaga agtcctcacc acccattgtg acagctactg ggtggagatg gcgagccttc aggtctttga aaagatgcac cgaatggatc tgtctgagag agcaaaggat gaagtcagag aagcagcttt gaaatccttt aataaaagga aacctctatc attagggata acacggaaag aacgaccacc tctagacgtg gacgaaatgc tggagcgctt caaaacagaa gcacaagcgt ttacagaaac gaaaggaaat gtcatctgcc tgggtaaaga agtctttaaa ggaaaaaagc cagacaaaga caataggtgc aggtatatat tgaagacgaa gttccgggag atgtggaaga gctggcctgg agatagcaaa gaggtccagg ttatggctga gagatacaag atgctgatcc cattcagcaa ccccagggtg cttcccgggc ccttctcata cacggtggtg ctgtatggtc ctgcaggcct tgggaaaacc acgctggccc agaaactaat gctagactgg gcagaggaca acctcatcca caaattcaaa tatgcgttct acctcagctg cagggagctc agccgcctgg gcccgtgcag ttttgcagag ctggtcttca gggactggcc tgaattgcag gatgacattc cacacatcct agcccaagca cggaaaatct tgttcgtgat tgacggcttt gatgagctgg gagccgcacc tggggcgctg atcgaggaca tctgcgggga ctgggagaag aagaagccgg tgcccgtcct cctggggagt ttgctgaaca gggtgatgtt acccaaggcc gccctgctgg tcaccacgcg gcccagggcc ctgagggacc tccggatcct ggcggaggag ccgatctaca taagggtgga gggcttcctg gaggaggaca ggagggccta tttcctgaga cactttggag acgaggacca agccatgcgt gcctttgagc taatgaggag caacgcggcc ctgttccagc tgggctcggc ccccgcggtg tgctggatcg tgtgcacgac tctgaagctg cagatggaga agggggagga cccggtcccc acctgcctca cccgcacggg gctgttcctg cgtttcctct gcagccggtt cccgcagggc gcacagctgc ggggcgcgct gcggacgctg agcctcctgg ccgcgcaggg cctgtgggcg cagacgtccg tgcttcaccg agaggatctg gaaaggctcg gggtgcagga gtccgacctc cgtctgttcc tggacggaga catcctccgc caggacagag tctccaaagg ctgctactcc ttcatccacc tcagcttcca gcagtttctc actgccctgt tctacaccct ggagaaggag gaggaagagg atagggacgg ccacacctgg gacattgggg acgtacagaa gctgctttcc ggagtagaaa gactcaggaa ccccgacctg atccaagcag gctactactc ctttggcctc gctaacgaga agagagccaa ggagttggag gccacttttg gctgccggat gtcaccggac atcaaacagg aattgctgcg atgcgacata agttgtaagg gtggacattc aacggtgaca gacctgcagg agctcctcgg ctgtctgtac gagtctcagg aggaggagct ggtgaaggag gtgatggctc agttcaaaga aatatccctg cacttaaatg cagtagacgt tgtgccatct tcattctgcg tcaagcactg tcgaaacctg cagaaaatgt cactgcaggt aataaaggag aatctcccgg agaatgtcac tgcgtctgaa tcagacgccg aggttgagag atcccaggat gatcagcaca tgcttccttt ctggacggac ctttgttcca tatttggatc aaataaggat ctgatgggtc tagcaatcaa tgatagcttt ctcagtgcct ccctagtaag gatcctgtgt gaacaaatag cctctgacac ctgtcatctc cagagagtgg tgttcaaaaa catttcccca gctgatgctc atcggaacct ctgcctagct cttcgaggtc acaagactgt aacgtatctg acccttcaag gcaatgacca ggatgatatg tttcccgcat tgtgtgaggt cttgagacat ccagaatgta acctgcgata tctcgggttg gtgtcttgtt ccgctaccac tcagcagtgg gctgatctct ccttggccct tgaagtcaac cagtccctga cgtgcgtaaa cctctccgac aatgagcttc tggatgaggg tgctaagttg ctgtacacaa ctttgagaca ccccaagtgc tttctgcaga ggttgtcgta a. It is sometimes possible for the material contained within the vial of "NLRP2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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