KCNH1 cdna clone
KCNH1 cDNA Clone
Gene Names
KCNH1; EAG; EAG1; ZLS1; TMBTS; h-eag; hEAG1; Kv10.1
Synonyms
KCNH1; KCNH1 cDNA Clone; KCNH1 cdna clone
Sequence
atgaccatggctgggggcaggaggggactagtggcccctcaaaacacgtttctggagaatattgttcggcggtccaatgatactaattttgtgttggggaatgctcagatagtggactggcctattgtgtacagcaatgatggattttgcaagctgtctggctatcacagggcagaagtgatgcaaaaaagcagcacctgcagttttatgtatggggagctgactgataaagacacgattgaaaaagtgcggcaaacatttgagaactatgagatgaattcctttgaaattctgatgtacaagaagaacaggacacctgtgtggttctttgtgaaaattgctccaattcgaaacgaacaggataaagtggttttatttctttgcactttcagtgacataacagctttcaaacagccaattgaggatgattcatgtaaaggctgggggaagtttgctcggctgacaagagcactgacaagcagcaggggtgtcctgcagcagctggctccaagcgtgcaaaaaggcgagaatgtccacaagcactcccgcctggcagaggtcctacagctgggctcagacatccttccccagtacaagcaagaggcaccaaagactccccctcacatcatcttacattattgtgtttttaagaccacgtgggattggatcatcttgatcttgaccttctatacagccatcttggtcccttataatgtctccttcaaaaccaggcagaataatgtggcctggctggttgttgatagcatcgtggatgttatctttttggtggacattgtgctcaattttcataccacctttgttggaccagcaggggaggtgatttctgaccccaaacttatccgcatgaactacctgaagacgtggtttgtgattgaccttctgtcctgtttgccatatgatgtcatcaacgcttttgagaacgtggatgagggcatcagcagcctgttcagctctctaaaagttgtccggctgctccgtcttgggcgagtggcccgtaagctggaccactacattgaatatggagctgctgtgctggtcctgctggtgtgtgtgtttgggctggctgcacactggatggcctgcatctggtacagcattggggactatgagatctttgacgaggacaccaagacaatccgcaacaacagctggctgtaccaactagcgatggacattggcaccccttaccagtttaatgggtctggctcagggaagtgggaaggtggtcccagcaagaattctgtctacatctcctcgttgtatttcacaatgaccagcctcaccagtgtgggctttgggaacatcgccccatccacagacattgagaagatctttgcagtggccatcatgatgattggctcacttctctatgccaccatcttcgggaatgtgacgactattttccaacagatgtatgccaacaccaacagataccatgagatgctcaacagtgttcgggacttcctgaagctctaccaggtgccaaaaggattgagtgagcgagtaatggattatattgtgtccacttggtccatgtccagaggcattgacacagagaaggtcctgcagatctgccccaaggacatgagagccgacatctgcgtgcacctgaaccgcaaggtgttcaaggagcacccggccttccggctggccagtgatggctgcctccgggcactggccatggagttccagacggtgcactgtgccccaggggacctcatctaccatgcaggagagagcgttgacagcctctgctttgtggtttctggctccctggaggtgatccaagatgatgaggtggtggccattctaggaaaaggagacgtgtttggagatgtgttctggaaggaagccacccttgcccagtcctgtgccaatgttagggccttgacctactgtgatctgcatgtgatcaagcgggatgccctgcagaaagtgctggaattctacacggccttctcccattccttctcccggaacctgattctgacgtacaacttgaggaagaggattgtgttccggaagatcagcgacgtgaaacgtgaagaggaagaacgcatgaaacgaaagaatgaggcccccctgatcttgcccccggaccaccctgtccggcgcctcttccagagattccgacagcagaaagaggccaggctggcagctgagagagggggccgggacctggatgacctagatgtggagaagggcaatgtccttacagagcatgcctccgccaaccacagcctcgtgaaggccagcgtggtcaccgtgcgtgagagtcctgccacgcccgtatccttccaggcagcctccacctccggggtgccagaccacgcaaagctacaggcgccagggtccgagtgcctgggccccaaggggggcgggggcgattgtgccaagcgcaaaagctgggcccgcttcaaagatgcttgcgggaagagtgaggactggaacaaggtgtccaaggctgagtcgatggagacacttcccgagaggacaaaagcgtcaggcgaggccacactgaagaagacagactcgtgtgacagtggcatcaccaagagcgacttgcgcctggacaacgtgggtgaggccaggagtccccaggatcggagtcccatcctggcagaggtcaagcattcgttctaccccatccctgagcagacgctgcaggccacagtcctggaggtgaggcacgagctgaaggaggacatcaaggccttaaacgccaaaatgaccaatattgagaaacagctctctgagatactcaggatattaacttccagaagatcctctcagtctcctcaggagttgtttgaaatatcgaggccacagtccccagaatcagagagagacatttttggagccagctga
Sequence Length
2889
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
108,597 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 1, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 1
NCBI Official Symbol
KCNH1
NCBI Official Synonym Symbols
EAG; EAG1; ZLS1; TMBTS; h-eag; hEAG1; Kv10.1
NCBI Protein Information
potassium voltage-gated channel subfamily H member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 1
Protein Family
UniProt Gene Name
KCNH1
UniProt Synonym Gene Names
EAG; EAG1; EAG channel 1; h-eag; hEAG1
UniProt Entry Name
KCNH1_HUMAN
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv10.1: Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: early endosome membrane; integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function: cyclic nucleotide binding; delayed rectifier potassium channel activity; protein binding
Biological Process: myoblast fusion; potassium ion transport; regulation of cell proliferation; regulation of membrane potential
Disease: Temple-baraitser Syndrome; Zimmermann-laband Syndrome 1
Research Articles on KCNH1
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Product Notes
The KCNH1 kcnh1 (Catalog #AAA1269166) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaccatgg ctgggggcag gaggggacta gtggcccctc aaaacacgtt tctggagaat attgttcggc ggtccaatga tactaatttt gtgttgggga atgctcagat agtggactgg cctattgtgt acagcaatga tggattttgc aagctgtctg gctatcacag ggcagaagtg atgcaaaaaa gcagcacctg cagttttatg tatggggagc tgactgataa agacacgatt gaaaaagtgc ggcaaacatt tgagaactat gagatgaatt cctttgaaat tctgatgtac aagaagaaca ggacacctgt gtggttcttt gtgaaaattg ctccaattcg aaacgaacag gataaagtgg ttttatttct ttgcactttc agtgacataa cagctttcaa acagccaatt gaggatgatt catgtaaagg ctgggggaag tttgctcggc tgacaagagc actgacaagc agcaggggtg tcctgcagca gctggctcca agcgtgcaaa aaggcgagaa tgtccacaag cactcccgcc tggcagaggt cctacagctg ggctcagaca tccttcccca gtacaagcaa gaggcaccaa agactccccc tcacatcatc ttacattatt gtgtttttaa gaccacgtgg gattggatca tcttgatctt gaccttctat acagccatct tggtccctta taatgtctcc ttcaaaacca ggcagaataa tgtggcctgg ctggttgttg atagcatcgt ggatgttatc tttttggtgg acattgtgct caattttcat accacctttg ttggaccagc aggggaggtg atttctgacc ccaaacttat ccgcatgaac tacctgaaga cgtggtttgt gattgacctt ctgtcctgtt tgccatatga tgtcatcaac gcttttgaga acgtggatga gggcatcagc agcctgttca gctctctaaa agttgtccgg ctgctccgtc ttgggcgagt ggcccgtaag ctggaccact acattgaata tggagctgct gtgctggtcc tgctggtgtg tgtgtttggg ctggctgcac actggatggc ctgcatctgg tacagcattg gggactatga gatctttgac gaggacacca agacaatccg caacaacagc tggctgtacc aactagcgat ggacattggc accccttacc agtttaatgg gtctggctca gggaagtggg aaggtggtcc cagcaagaat tctgtctaca tctcctcgtt gtatttcaca atgaccagcc tcaccagtgt gggctttggg aacatcgccc catccacaga cattgagaag atctttgcag tggccatcat gatgattggc tcacttctct atgccaccat cttcgggaat gtgacgacta ttttccaaca gatgtatgcc aacaccaaca gataccatga gatgctcaac agtgttcggg acttcctgaa gctctaccag gtgccaaaag gattgagtga gcgagtaatg gattatattg tgtccacttg gtccatgtcc agaggcattg acacagagaa ggtcctgcag atctgcccca aggacatgag agccgacatc tgcgtgcacc tgaaccgcaa ggtgttcaag gagcacccgg ccttccggct ggccagtgat ggctgcctcc gggcactggc catggagttc cagacggtgc actgtgcccc aggggacctc atctaccatg caggagagag cgttgacagc ctctgctttg tggtttctgg ctccctggag gtgatccaag atgatgaggt ggtggccatt ctaggaaaag gagacgtgtt tggagatgtg ttctggaagg aagccaccct tgcccagtcc tgtgccaatg ttagggcctt gacctactgt gatctgcatg tgatcaagcg ggatgccctg cagaaagtgc tggaattcta cacggccttc tcccattcct tctcccggaa cctgattctg acgtacaact tgaggaagag gattgtgttc cggaagatca gcgacgtgaa acgtgaagag gaagaacgca tgaaacgaaa gaatgaggcc cccctgatct tgcccccgga ccaccctgtc cggcgcctct tccagagatt ccgacagcag aaagaggcca ggctggcagc tgagagaggg ggccgggacc tggatgacct agatgtggag aagggcaatg tccttacaga gcatgcctcc gccaaccaca gcctcgtgaa ggccagcgtg gtcaccgtgc gtgagagtcc tgccacgccc gtatccttcc aggcagcctc cacctccggg gtgccagacc acgcaaagct acaggcgcca gggtccgagt gcctgggccc caaggggggc gggggcgatt gtgccaagcg caaaagctgg gcccgcttca aagatgcttg cgggaagagt gaggactgga acaaggtgtc caaggctgag tcgatggaga cacttcccga gaggacaaaa gcgtcaggcg aggccacact gaagaagaca gactcgtgtg acagtggcat caccaagagc gacttgcgcc tggacaacgt gggtgaggcc aggagtcccc aggatcggag tcccatcctg gcagaggtca agcattcgtt ctaccccatc cctgagcaga cgctgcaggc cacagtcctg gaggtgaggc acgagctgaa ggaggacatc aaggccttaa acgccaaaat gaccaatatt gagaaacagc tctctgagat actcaggata ttaacttcca gaagatcctc tcagtctcct caggagttgt ttgaaatatc gaggccacag tccccagaat cagagagaga catttttgga gccagctga. It is sometimes possible for the material contained within the vial of "KCNH1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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