SPINLW1 cdna clone
SPINLW1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Description
Spinlw1: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Cancer Testis Antigen (CTA); Inhibitor; Secreted
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cell surface; extracellular space; protein complex
Molecular Function: protein binding
Biological Process: defense response to bacterium; negative regulation of peptidase activity; protein oligomerization
Research Articles on SPINLW1
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Product Notes
The SPINLW1 eppin (Catalog #AAA1268681) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggatctt ctggactttt gagcctcctg gtgctattcg tcctcttagc gaatgtccag ggacctggtc tgactgattg gttatttccc aggagatgtc ccaaaatcag agaagaatgt gaattccaag aaagggatgt gtgtacaaag gacagacaat gccaggacaa caagaagtgt tgtgtcttca gctgcggaaa aaaatgttta gatctcaaac aagatgtatg cgaaatgcca aaagaaactg gcccctgcct ggcttatttt cttcattggt ggtatgacaa gaaagataat acttgctcca tgtttgtcta tggtggctgc cagggaaaca ataacaactt ccaatccaaa gccaactgcc tgaacacctg caagaataaa cgctttccct ga. It is sometimes possible for the material contained within the vial of "SPINLW1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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