PLCG2 cdna clone
PLCG2 cDNA Clone
Gene Names
PLCG2; FCAS3; APLAID; PLC-IV; PLC-gamma-2
Synonyms
PLCG2; PLCG2 cDNA Clone; PLCG2 cdna clone
Sequence
atgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagagagccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcggagaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgccgacaagatcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaagatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatatggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagttaactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccaccattatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagcatcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgccaagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaacagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaattcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgctgtttacctgcgtgacttccagaggtttctcatacatgaacagcaggagcattgggctcaggatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaactgctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagcatctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcattactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcgtccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgctgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatcaagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacgtcgagcttcccagtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggccttcaaggaagtatttggcgacctgctgttgacgaagcccacggaggccagtgctgaccagctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccccgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggggagctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccattgccgatgccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggatataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagaggacgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcaccttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtcaggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactacttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacgcacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccccacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctgatgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctatgccatcaccttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccggcactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactacgagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctggagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtggatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactacaaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctccaaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttcccatccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattattgaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtcgtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagcagcagggctatcctccggtggagtttgccacagacagggtggaggagctctttgagtggtttcagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaaccagcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggagacgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaagggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttccgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagtacatgcagatgaatcacgcattgttttctctcaacgggcgcacgggctacgttctgcagcctgagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctgatgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtattgcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaagacgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtgacatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagatatgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcagtcaaatcaggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctcctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgtcgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacaccagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaaccagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaacagcaagttttactcatag
Sequence Length
3798
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
147,870 Da
NCBI Official Full Name
Homo sapiens phospholipase C, gamma 2 (phosphatidylinositol-specific), mRNA
NCBI Official Synonym Full Names
phospholipase C gamma 2
NCBI Official Symbol
PLCG2
NCBI Official Synonym Symbols
FCAS3; APLAID; PLC-IV; PLC-gamma-2
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Protein Family
UniProt Gene Name
PLCG2
UniProt Synonym Gene Names
PLC-IV; PLC-gamma-2
UniProt Entry Name
PLCG2_HUMAN
NCBI Description
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Uniprot Description
PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: cytosol; plasma membrane
Molecular Function: phosphoinositide phospholipase C activity; phospholipase C activity; protein binding
Biological Process: B cell differentiation; B cell receptor signaling pathway; inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; platelet activation; release of sequestered calcium ion into cytosol; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; Wnt receptor signaling pathway
Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
Research Articles on PLCG2
Similar Products
Product Notes
The PLCG2 plcg2 (Catalog #AAA1268514) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccacca cggtcaatgt agattccctt gcggaatatg agaagagcca gatcaagaga gccctggagc tggggacggt gatgactgtg ttcagcttcc gcaagtccac ccccgagcgg agaaccgtcc aggtgatcat ggagacgcgg caggtggcct ggagcaagac cgccgacaag atcgagggct tcttggatat catggaaata aaagaaatcc gcccagggaa gaactccaaa gatttcgagc gagcaaaagc agttcgccag aaagaagact gctgcttcac catcctatat ggcactcagt tcgtcctcag cacgctcagc ttggcagctg actctaaaga ggatgcagtt aactggctct ctggcttgaa aatcttacac caggaagcga tgaatgcgtc cacgcccacc attatcgaga gttggctgag aaagcagata tattctgtgg atcaaaccag aagaaacagc atcagtctcc gagagttgaa gaccatcttg cccctgatca actttaaagt gagcagtgcc aagttcctta aagataagtt tgtggaaata ggagcacaca aagatgagct cagctttgaa cagttccatc tcttctataa aaaacttatg tttgaacagc aaaaatcgat tctcgatgaa ttcaaaaagg attcgtccgt gttcatcctg gggaacactg acaggccgga tgcctctgct gtttacctgc gtgacttcca gaggtttctc atacatgaac agcaggagca ttgggctcag gatctgaaca aagtccgtga gcggatgaca aagttcattg atgacaccat gcgtgaaact gctgagcctt tcttgtttgt ggatgagttc ctcacgtacc tgttttcacg agaaaacagc atctgggatg agaagtatga cgcggtggac atgcaggaca tgaacaaccc cctgtctcat tactggatct cctcgtcaca taacacgtac cttacaggtg accagctgcg gagcgagtcg tccccagaag cttacatccg ctgcctgcgc atgggctgtc gctgcattga actggactgc tgggacgggc ccgatgggaa gccggtcatc taccatggct ggacgcggac taccaagatc aagtttgacg acgtcgtgca ggccatcaaa gaccacgcct ttgttacgtc gagcttccca gtgatcctgt ccatcgagga gcactgcagc gtggagcaac agcgtcacat ggccaaggcc ttcaaggaag tatttggcga cctgctgttg acgaagccca cggaggccag tgctgaccag ctgccctcgc ccagccagct gcgggagaag atcatcatca agcataagaa gctgggcccc cgaggcgatg tggatgtcaa catggaggac aagaaggacg aacacaagca acagggggag ctgtacatgt gggattccat tgaccagaaa tggactcggc actactgcgc cattgccgat gccaagctgt ccttcagtga tgacattgaa cagactatgg aggaggaagt gccccaggat atacccccta cagaactaca ttttggggag aaatggttcc acaagaaggt ggagaagagg acgagtgccg agaagttgct gcaggaatac tgcatggaga cggggggcaa ggatggcacc ttcctggttc gggagagcga gaccttcccc aatgactaca ccctgtcctt ctggcggtca ggccgggtcc agcactgccg gatccgctcc accatggagg gcgggaccct gaaatactac ttgactgaca acctcacctt cagcagcatc tatgccctca tccagcacta ccgcgagacg cacctgcgct gcgccgagtt cgagctgcgg ctcacggacc ctgtgcccaa ccccaacccc cacgagtcca agccgtggta ctatgacagc ctgagccgcg gagaggcaga ggacatgctg atgaggattc cccgggacgg ggccttcctg atccggaagc gagaggggag cgactcctat gccatcacct tcagggctag gggcaaggta aagcattgtc gcatcaaccg ggacggccgg cactttgtgc tggggacctc cgcctatttt gagagtctgg tggagctcgt cagttactac gagaagcatt cactctaccg aaagatgaga ctgcgctacc ccgtgacccc cgagctcctg gagcgctaca atatggaaag agatataaac tccctctacg acgtcagcag aatgtatgtg gatcccagtg aaatcaatcc gtccatgcct cagagaaccg tgaaagctct gtatgactac aaagccaagc gaagcgatga gctgagcttc tgccgtggtg ccctcatcca caatgtctcc aaggagcccg ggggctggtg gaaaggagac tatggaacca ggatccagca gtacttccca tccaactacg tcgaggacat ctcaactgca gacttcgagg agctagaaaa gcagattatt gaagacaatc ccttagggtc tctttgcaga ggaatattgg acctcaatac ctataacgtc gtgaaagccc ctcagggaaa aaaccagaag tcctttgtct tcatcctgga gcccaagcag cagggctatc ctccggtgga gtttgccaca gacagggtgg aggagctctt tgagtggttt cagagcatcc gagagatcac ctggaagatt gacaccaagg agaacaacat gaagtactgg gagaagaacc agtccatcgc catcgagctc tctgacctgg ttgtctactg caaaccaacc agcaaaacca aggacaactt agaaaatcct gacttccgag aaatccgctc ctttgtggag acgaaggctg acagcatcat cagacagaag cccgtcgacc tcctgaagta caatcaaaag ggcctgaccc gcgtctaccc aaagggacaa agagttgact cttcaaacta cgaccccttc cgcctctggc tgtgcggttc tcagatggtg gcactcaatt tccagacggc agataagtac atgcagatga atcacgcatt gttttctctc aacgggcgca cgggctacgt tctgcagcct gagagcatga ggacagagaa atatgacccg atgccacccg agtcccagag gaagatcctg atgacgctga cagtcaaggt tctcggtgct cgccatctcc ccaaacttgg acgaagtatt gcctgtccct ttgtagaagt ggagatctgt ggagccgagt atgacaacaa caagttcaag acgacggttg tgaatgataa tggcctcagc cctatctggg ctccaacaca ggagaaggtg acatttgaaa tttatgaccc aaacctggca tttctgcgct ttgtggttta tgaagaagat atgttcagcg atcccaactt tcttgctcat gccacttacc ccattaaagc agtcaaatca ggattcaggt ccgttcctct gaagaatggg tacagcgagg acatagagct ggcttccctc ctggttttct gtgagatgcg gccagtcctg gagagcgaag aggaacttta ctcctcctgt cgccagctga ggaggcggca agaagaactg aacaaccagc tctttctgta tgacacacac cagaacttgc gcaatgccaa ccgggatgcc ctggttaaag agttcagtgt taatgagaac cagctccagc tgtaccagga gaaatgcaac aagaggttaa gagagaagag agtcagcaac agcaagtttt actcatag. It is sometimes possible for the material contained within the vial of "PLCG2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
