DAPK1 cdna clone
DAPK1 cDNA Clone
Gene Names
DAPK1; DAPK
Synonyms
DAPK1; DAPK1 cDNA Clone; DAPK1 cdna clone
Sequence
atgaccgtgttcaggcaggaaaacgtggatgattactacgacaccggcgaggaacttggcagtggacagtttgcggttgtgaagaaatgccgtgagaaaagcaccggcctccagtatgccgccaaattcatcaagaaaaggaggactaagtccagccggcggggtgtgagccgcgaggacatcgagcgggaggtcagcatcctgaaggagatccagcaccccaatgtcatcaccctgcacgaggtctatgagaacaagacggacgtcatcctgatcttggaactcgttgcaggtggcgagctgtttgacttcttagctgaaaaggaatctttaactgaagaggaagcaactgaatttctcaaacaaattcttaatggtgtttactacctgcactcccttcaaatcgcccactttgatcttaagcctgagaacataatgcttttggatagaaatgtccccaaacctcggatcaagatcattgactttgggttggcccataaaattgactttggaaatgaatttaaaaacatatttgggactccagagtttgtcgctcctgagatagtcaactatgaacctcttggtcttgaggcagatatgtggagtatcggggtaataacctatatcctcctaagtggggcctccccatttcttggagacactaagcaagaaacgttagcaaatgtatccgctgtcaactacgaatttgaggatgaatacttcagtaataccagtgccctagccaaagatttcataagaagacttctggtcaaggatccaaagaagagaatgacaattcaagatagtttgcagcatccctggatcaagcctaaagatacacaacaggcacttagtagaaaagcatcagcagtaaacatggagaaattcaagaagtttgcagcccggaaaaaatggaaacaatccgttcgcttgatatcactgtgccaaagattatccaggtcattcctgtccagaagtaacatgagtgttgccagaagcgatgatactctggatgaggaagactcctttgtgatgaaagccatcatccatgccatcaacgatgacaatgtcccaggcctgcagcaccttctgggctcattatccaactatgatgttaaccaacccaacaagcacgggacacctccattactcattgctgctggctgtgggaatattcaaatactacagttgctcattaaaagaggctcgagaatcgatgtccaggataagggcgggtccaatgccgtctactgggctgctcggcatggccacgtcgataccttgaaatttctcagtgagaacaaatgccctttggatgtgaaagacaagtctggagagatggccctccacgtggcagctcgctatggccatgctgacgtggctcagttactgtgcagcttcggctcaaatcccaatatccaggacaaggaagaagaaacccccctgcactgtgctgcttggcacggctattactctgtggccaaagccctttgtgaagccggctgtaacgtgaacatcaagaaccgagaaggagagacgcccctcctgacagcctctgccaggggctaccacgacatcgtggagtgtctggccgaacatggagccgaccttaatgcttgcgacaaggacggacacattgcccttcatctggctgtaagacggtgtcagatggaggtaatcaagactctcctcagccaagggtgtttcgtcgattatcaagacaggcacggcaatactcccctccatgtggcatgtaaagatggcaacatgcctatcgtggtggccctctgtgaagcaaactgcaatttggacatctccaacaagtatgggcgaacgcctctgcaccttgcggccaacaacggaatcctagacgtggtccggtatctctgtctgatgggagccagcgttgaggcgctgaccacggacggaaagacggcagaagatcttgctagatcggaacagcacgagcacgtagcaggtctccttgcaagacttcgaaaggatacgcaccgaggactcttcatccagcagctccgacccacacagaacctgcagccaagaattaagctcaagctgtttggccactcgggatccgggaaaaccacccttgtagaatctctcaagtgtgggctgctgaggagctttttcagaaggcgtcggcccagactgtcttccaccaactccagcaggttcccaccttcacccctggcttctaagcccacagtctcagtgagcatcaacaacctgtacccaggctgcgagaacgtgagtgtgaggagccgcagcatgatgttcgagccgggtcttaccaaagggatgctggaggtgtttgtggccccgacccaccacccgcactgctcggccgatgaccagtccaccaaggccatcgacatccagaacgcttatttgaatggagttggcgatttcagcgtgtgggagttctctggaaatcctgtgtatttctgctgttatgactattttgctgcaaatgatcccacgtcaatccatgttgttgtctttagtctagaagagccctatgagatccagctgaaccaagtgattttctggctcagtttcctgaagtcccttgtcccagttgaagaacccatagccttcggtggcaagctgaagaacccactccaagttgtcctggtggccacccacgctgacatcatgaatgttcctcgaccggctggaggcgagtttggatatgacaaagacacatcgttgctgaaagagattaggaacaggtttggaaatgatcttcacatttcaaataagctgtttgttctggatgctggggcttctgggtcaaaggacatgaaggtacttcgaaatcatctgcaagaaatacgaagccagattgtttcggtctgtcctcccatgactcacctgtgtgagaaaatcatctccacgctgccttcctggaggaagctcaatggacccaaccagctgatgtcgctgcagcagtttgtgtacgacgtgcaggaccagctgaaccccctggccagcgaggaggacctcaggcgcattgctcagcagctccacagcacaggcgagatcaacatcatgcaaagtgaaacagttcaggacgtgctgctcctggacccccgctggctctgcacaaacgtcctggggaagttgctgtccgtggagaccccacgggcgctgcaccactaccggggccgctacaccgtggaggacatccagcgcctggtgcccgacagcgacgtggaggagctgctgcagatcctcgatgccatggacatctgcgcccgggacctgagcagcgggaccatggtggacgtcccagccctgatcaagacagacaacctgcaccgctcctgggctgatgaggaggacgaggtgatggtgtatggtggcgtgcgcatcgtgcccgtggaacacctcacccccttcccatgtggcatctttcacaaggtccaggtgaacctgtgccggtggatccaccagcaaagcacagagggcgacgcggacatccgcctgtgggtgaatggctgcaagctggccaaccgtggggccgagctgctggtgctgctggtcaaccacggccagggcattgaggtccaggtccgcggcctggagacggagaagatcaagtgctgcctgctgctggactcggtgtgcagcaccattgagaacgtcatggccaccacgctgccagggctcctgaccgtgaagcattacctgagcccccagcagctgcgggagcaccatgagcccgtcatgatctaccagccacgggacttcttccgggcacagactctgaaggaaacctcactgaccaacaccatgggggggtacaaggaaagcttcagcagcatcatgtgcttcgggtgtcacgacgtctactcacaggccagcctcggcatggacatccatgcatcagacctgaacctcctcactcggaggaaactgagtcgcctgctggacccgcccgaccccctggggaaggactggtgccttctcgccatgaacttaggcctccctgacctcgtggcaaagtacaacaccagtaacggggctcccaaggatttcctccccagccccctccacgccctgctgcgggaatggaccacctaccctgagagcacagtgggcaccctcatgtccaaactgagggagctgggtcgccgggatgccgcagactttttgctgaaggcatcctctgtgttcaaaatcaacctggatggcaatggccaggaggcctatgcctcgagctgcaacagcggcacctcttacaattccattagctctgttgtatcccggtga
Sequence Length
4293
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
152,467 Da
NCBI Official Full Name
Homo sapiens death-associated protein kinase 1, mRNA
NCBI Official Synonym Full Names
death associated protein kinase 1
NCBI Official Symbol
DAPK1
NCBI Official Synonym Symbols
DAPK
NCBI Protein Information
death-associated protein kinase 1
UniProt Protein Name
Death-associated protein kinase 1
Protein Family
UniProt Gene Name
DAPK1
UniProt Synonym Gene Names
DAPK; DAP kinase 1
UniProt Entry Name
DAPK1_HUMAN
NCBI Description
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Description
DAPK1: a CAMK protein kinase of the Death-associated protein kinase (DAPK) family. Mediates autophagy and is a positive mediator of ER stress-induced and gamma-interferon induced programmed cell death. Catalytic activity is increased by ER stress. Inhibited by autophosphorylation of S308. DAPK -/- cells are protected from ER stress-induced cell death, and both apoptosis and autophagy are decreased. Colocalizes with the actin filament system. It is a tumor suppressor candidate, activating p53-dependent apoptosis. Expression is reduced in some cancers, and the promoter is frequently hypermethylated in invasive cancers. Increased expression and mislocalization is seen in epilepsy, where it may regulate neuronal death. A structurally unique serine-threonine kinase that carries eight ankyrin repeats and two putative P-loop consensus sites. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Autophagy; CAMK group; DAPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component: actin cytoskeleton; cytoplasm; plasma membrane
Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; syntaxin-1 binding
Biological Process: apoptosis; negative regulation of translation; positive regulation of caspase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
Research Articles on DAPK1
Similar Products
Product Notes
The DAPK1 dapk1 (Catalog #AAA1267862) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaccgtgt tcaggcagga aaacgtggat gattactacg acaccggcga ggaacttggc agtggacagt ttgcggttgt gaagaaatgc cgtgagaaaa gcaccggcct ccagtatgcc gccaaattca tcaagaaaag gaggactaag tccagccggc ggggtgtgag ccgcgaggac atcgagcggg aggtcagcat cctgaaggag atccagcacc ccaatgtcat caccctgcac gaggtctatg agaacaagac ggacgtcatc ctgatcttgg aactcgttgc aggtggcgag ctgtttgact tcttagctga aaaggaatct ttaactgaag aggaagcaac tgaatttctc aaacaaattc ttaatggtgt ttactacctg cactcccttc aaatcgccca ctttgatctt aagcctgaga acataatgct tttggataga aatgtcccca aacctcggat caagatcatt gactttgggt tggcccataa aattgacttt ggaaatgaat ttaaaaacat atttgggact ccagagtttg tcgctcctga gatagtcaac tatgaacctc ttggtcttga ggcagatatg tggagtatcg gggtaataac ctatatcctc ctaagtgggg cctccccatt tcttggagac actaagcaag aaacgttagc aaatgtatcc gctgtcaact acgaatttga ggatgaatac ttcagtaata ccagtgccct agccaaagat ttcataagaa gacttctggt caaggatcca aagaagagaa tgacaattca agatagtttg cagcatccct ggatcaagcc taaagataca caacaggcac ttagtagaaa agcatcagca gtaaacatgg agaaattcaa gaagtttgca gcccggaaaa aatggaaaca atccgttcgc ttgatatcac tgtgccaaag attatccagg tcattcctgt ccagaagtaa catgagtgtt gccagaagcg atgatactct ggatgaggaa gactcctttg tgatgaaagc catcatccat gccatcaacg atgacaatgt cccaggcctg cagcaccttc tgggctcatt atccaactat gatgttaacc aacccaacaa gcacgggaca cctccattac tcattgctgc tggctgtggg aatattcaaa tactacagtt gctcattaaa agaggctcga gaatcgatgt ccaggataag ggcgggtcca atgccgtcta ctgggctgct cggcatggcc acgtcgatac cttgaaattt ctcagtgaga acaaatgccc tttggatgtg aaagacaagt ctggagagat ggccctccac gtggcagctc gctatggcca tgctgacgtg gctcagttac tgtgcagctt cggctcaaat cccaatatcc aggacaagga agaagaaacc cccctgcact gtgctgcttg gcacggctat tactctgtgg ccaaagccct ttgtgaagcc ggctgtaacg tgaacatcaa gaaccgagaa ggagagacgc ccctcctgac agcctctgcc aggggctacc acgacatcgt ggagtgtctg gccgaacatg gagccgacct taatgcttgc gacaaggacg gacacattgc ccttcatctg gctgtaagac ggtgtcagat ggaggtaatc aagactctcc tcagccaagg gtgtttcgtc gattatcaag acaggcacgg caatactccc ctccatgtgg catgtaaaga tggcaacatg cctatcgtgg tggccctctg tgaagcaaac tgcaatttgg acatctccaa caagtatggg cgaacgcctc tgcaccttgc ggccaacaac ggaatcctag acgtggtccg gtatctctgt ctgatgggag ccagcgttga ggcgctgacc acggacggaa agacggcaga agatcttgct agatcggaac agcacgagca cgtagcaggt ctccttgcaa gacttcgaaa ggatacgcac cgaggactct tcatccagca gctccgaccc acacagaacc tgcagccaag aattaagctc aagctgtttg gccactcggg atccgggaaa accacccttg tagaatctct caagtgtggg ctgctgagga gctttttcag aaggcgtcgg cccagactgt cttccaccaa ctccagcagg ttcccacctt cacccctggc ttctaagccc acagtctcag tgagcatcaa caacctgtac ccaggctgcg agaacgtgag tgtgaggagc cgcagcatga tgttcgagcc gggtcttacc aaagggatgc tggaggtgtt tgtggccccg acccaccacc cgcactgctc ggccgatgac cagtccacca aggccatcga catccagaac gcttatttga atggagttgg cgatttcagc gtgtgggagt tctctggaaa tcctgtgtat ttctgctgtt atgactattt tgctgcaaat gatcccacgt caatccatgt tgttgtcttt agtctagaag agccctatga gatccagctg aaccaagtga ttttctggct cagtttcctg aagtcccttg tcccagttga agaacccata gccttcggtg gcaagctgaa gaacccactc caagttgtcc tggtggccac ccacgctgac atcatgaatg ttcctcgacc ggctggaggc gagtttggat atgacaaaga cacatcgttg ctgaaagaga ttaggaacag gtttggaaat gatcttcaca tttcaaataa gctgtttgtt ctggatgctg gggcttctgg gtcaaaggac atgaaggtac ttcgaaatca tctgcaagaa atacgaagcc agattgtttc ggtctgtcct cccatgactc acctgtgtga gaaaatcatc tccacgctgc cttcctggag gaagctcaat ggacccaacc agctgatgtc gctgcagcag tttgtgtacg acgtgcagga ccagctgaac cccctggcca gcgaggagga cctcaggcgc attgctcagc agctccacag cacaggcgag atcaacatca tgcaaagtga aacagttcag gacgtgctgc tcctggaccc ccgctggctc tgcacaaacg tcctggggaa gttgctgtcc gtggagaccc cacgggcgct gcaccactac cggggccgct acaccgtgga ggacatccag cgcctggtgc ccgacagcga cgtggaggag ctgctgcaga tcctcgatgc catggacatc tgcgcccggg acctgagcag cgggaccatg gtggacgtcc cagccctgat caagacagac aacctgcacc gctcctgggc tgatgaggag gacgaggtga tggtgtatgg tggcgtgcgc atcgtgcccg tggaacacct cacccccttc ccatgtggca tctttcacaa ggtccaggtg aacctgtgcc ggtggatcca ccagcaaagc acagagggcg acgcggacat ccgcctgtgg gtgaatggct gcaagctggc caaccgtggg gccgagctgc tggtgctgct ggtcaaccac ggccagggca ttgaggtcca ggtccgcggc ctggagacgg agaagatcaa gtgctgcctg ctgctggact cggtgtgcag caccattgag aacgtcatgg ccaccacgct gccagggctc ctgaccgtga agcattacct gagcccccag cagctgcggg agcaccatga gcccgtcatg atctaccagc cacgggactt cttccgggca cagactctga aggaaacctc actgaccaac accatggggg ggtacaagga aagcttcagc agcatcatgt gcttcgggtg tcacgacgtc tactcacagg ccagcctcgg catggacatc catgcatcag acctgaacct cctcactcgg aggaaactga gtcgcctgct ggacccgccc gaccccctgg ggaaggactg gtgccttctc gccatgaact taggcctccc tgacctcgtg gcaaagtaca acaccagtaa cggggctccc aaggatttcc tccccagccc cctccacgcc ctgctgcggg aatggaccac ctaccctgag agcacagtgg gcaccctcat gtccaaactg agggagctgg gtcgccggga tgccgcagac tttttgctga aggcatcctc tgtgttcaaa atcaacctgg atggcaatgg ccaggaggcc tatgcctcga gctgcaacag cggcacctct tacaattcca ttagctctgt tgtatcccgg tga. It is sometimes possible for the material contained within the vial of "DAPK1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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