SERPINF1 cdna clone
SERPINF1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]
Uniprot Description
PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.
Protein type: Secreted; Inhibitor; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: protein binding; serine-type endopeptidase inhibitor activity
Biological Process: cell proliferation; multicellular organismal development; negative regulation of angiogenesis; positive regulation of neurogenesis
Disease: Osteogenesis Imperfecta, Type Vi
Research Articles on SERPINF1
Similar Products
Product Notes
The SERPINF1 serpinf1 (Catalog #AAA1267827) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcaggccc tggtgctact cctctgcatt ggagccctcc tcgggcacag cagctgccag aaccctgcca gccccccgga ggagggctcc ccagaccccg acagcacagg ggcgctggtg gaggaggagg atcctttctt caaagtcccc gtgaacaagc tggcagcggc tgtctccaac ttcggctatg acctgtaccg ggtgcgatcc agcatgagcc ccacgaccaa cgtgctcctg tctcctctca gtgtggccac ggccctctcg gccctctcgc tgggagcgga gcagcgaaca gaatccatca ttcaccgggc tctctactat gacttgatca gcagcccaga catccatggt acctataagg agctccttga cacggtcact gcccgccaga agaacctcaa gagtgcctcc cggatcgtct ttgagaagaa gctgcgcata aaatccagct ttgtggcacc tctggaaaag tcatatggga ccaggcccag agtcctgacg ggcaaccctc gcttggacct gcaagagatc aacaactggg tgcaggcgca gatgaaaggg aagctcgcca ggtccacaaa ggaaattccc gatgagatca gcattctcct tctcggtgtg gcgcacttca aggggcagtg ggtaacaaag tttgactcca gaaagacttc cctcgaggat ttctacttgg atgaagagag gaccgtgagg gtccccatga tgtcggaccc taaggctgtt ttacgctatg gcttggattc agatctcagc tgcaagattg cccagctgcc cttgaccgga agcatgagta tcatcttctt cctgcccctg aaagtgaccc agaatttgac cttgatagag gagagcctca cctccgagtt cattcatgac atagaccgag aactgaagac cgtgcaggcg gtcctcactg tccccaagct gaagctgagt tacgaaggcg aagtcaccaa gtccctgcag gagatgaagc tgcaatcctt gtttgattca ccagacttta gcaagatcac aggcaaaccc atcaagctga ctcaggtgga acaccgggct ggctttgagt ggaacgagga tggggcggga accaccccca gcccagggct gcagcctgcc cacctcacct tcccgctgga ctatcacctt aaccagcctt tcatcttcgt actgagggac acagacacag gggcccttct cttcattggc aagattctgg accccagggg cccctaa. It is sometimes possible for the material contained within the vial of "SERPINF1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
