CCBL1 cdna clone
CCBL1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.6.1.7; EC 2.6.1.64; Transferase; EC 4.4.1.13; Lyase
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity
Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process
Research Articles on CCBL1
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Product Notes
The CCBL1 kyat1 (Catalog #AAA1267125) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccaaac agctgcaggc ccgaaggcta gacgggatcg actacaaccc ctgggtggag tttgtgaaac tggccagtga gcatgacgtc gtgaacttgg gccagggctt cccggatttc ccaccaccag actttgccgt ggaagccttt cagcacgctg tcagtggaga cttcatgctt aaccagtaca ccaagacatt tggttaccca ccactgacga agatcctggc aagtttcttt ggggagctgc tgggtcagga gatagacccg ctcaggaatg tgctggtgac tgttggtggc tatggggccc tgttcacagc cttccaggcc ctggtggacg aaggagacga ggtcatcatc atcgaaccct tttttgactg ctacgagccc atgacaatga tggcaggggg tcgtcctgtg tttgtgtccc tgaagccggg tcccatccag aatggagaac tgggttccag cagcaactgg cagctggacc ccatggagct ggccggcaaa ttcacatcac gcaccaaagc cctggtcctc aacaccccca acaaccccct gggcaaggtg ttctccaggg aagagctgga gctggtggcc agcctttgcc agcagcatga cgtggtgtgt atcactgatg aagtctacca gtggatggtc tacgacgggc accagcacat cagcattgtc tcagcagctg ttctgttcgg ccttgggcag ccagcctccc tggcatgtgg gaacggaccc tga. It is sometimes possible for the material contained within the vial of "CCBL1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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