CORIN cdna clone
CORIN cDNA Clone
Gene Names
CORIN; CRN; ATC2; Lrp4; PEE5; TMPRSS10
Synonyms
CORIN; CORIN cDNA Clone; CORIN cdna clone
Sequence
ATGAAACAGTCTCCTGCCCTCGCTCCGGAAGAGCGCTACCGCAGAGCCGGGTCCCCAAAGCCGGTCTTGAGAGCTGATGACAATAACATGGGCAATGGCTGCTCTCAGAAGCTGGCGACTGCTAACCTCCTCCGGTTCCTATTGCTGGTCCTGATTCCATGTATCTGTGCTCTCGTTCTCTTGCTGGTGATCCTGCTTTCCTATGTTGGAACATTACAAAAGGTCTATTTTAAATCAAATGGGAGTGAACCTTTGGTCACTGATGGTGAAATCCAAGGGTCCGATGTTATTCTTACAAATACAATTTATAACCAGAGCACTGTGGTGTCTACTGCACATCCCGACCAACACGTTCCAGCCTGGACTACGGATGCTTCTCTCCCAGGGGACCAAAGTCACAGGAATACAAGTGCCTGTATGAACATCACCCACAGCCAGTGTCAGATGCTGCCCTACCACGCCACGCTGACACCTCTCCTCTCAGTTGTCAGAAACATGGAAATGGAAAAGTTCCTCAAGTTTTTCACATATCTCCATCGCCTCAGTTGCTATCAACATATCATGCTGTTTGGCTGTACCCTCGCCTTCCCTGAGTGCATCATTGATGGCGATGACAGTCATGGACTCCTGCCCTGTAGGTCCTTCTGTGAGGCTGCAAAAGAAGGCTGTGAATCAGTCCTGGGGATGGTGAATTACTCCTGGCCGGATTTCCTCAGATGCTCCCAGTTTAGAAACCAAACTGAAAGCAGCAATGTCAGCAGAATTTGCTTCTCACCTCAGCAGGAAAACGGAAAGCAATTGCTCTGTGGAAGGGGTGAGAACTTTCTGTGTGCCAGTGGAATCTGCATCCCCGGGAAACTGCAATGTAATGGCTACAACGACTGTGACGACTGGAGTGACGAGGCTCATTGCAACTGCAGCGAGAATCTGTTTCACTGTCACACAGGCAAGTGCCTTAATTACAGCCTTGTGTGTGATGGATATGATGACTGTGGGGATTTGAGTGATGAGCAAAACTGTGATTGCAATCCCACAACAGAGCATCGCTGCGGGGACGGGCGCTGCATCGCCATGGAGTGGGTGTGTGATGGTGACCACGACTGTGTGGATAAGTCCGACGAGGTCAACTGCTCCTGTCACAGCCAGGGTCTGGTGGAATGCAGAAATGGACAATGTATCCCCAGCACGTTTCAATGTGATGGTGACGAGGACTGCAAGGATGGGAGTGATGAGGAGAACTGCAGCGTCATTCAGACTTCATGTCAAGAAGGAGACCAAAGATGCCTCTACAATCCCTGCCTTGATTCATGTGGTGGTAGCTCTCTCTGTGACCCGAACAACAGTCTGAATAACTGTAGTCAATGTGAACCAATTACATTGGAACTCTGCATGAATTTGCCCTACAACAGTACAAGTTATCCAAATTATTTTGGCCACAGGACTCAAAAGGAAGCATCCATCAGCTGGGAGTCTTCTCTTTTCCCTGCACTTGTTCAAACCAACTGTTATAAATACCTCATGTTCTTTTCTTGCACCATTTTGGTACCAAAATGTGATGTGAATACAGGCGAGCGTATCCCTCCTTGCAGGGCATTGTGTGAACACTCTAAAGAACGCTGTGAGTCTGTTCTTGGGATTGTGGGCCTACAGTGGCCTGAAGACACAGATTGCAGTCAATTTCCAGAGGAAAATTCAGACAATCAAACCTGCCTGATGCCTGATGAATATGTGGAAGAATGCTCACCTAGTCATTTCAAGTGCCGCTCAGGACAGTGTGTTCTGGCTTCCAGAAGATGTGATGGCCAGGCCGACTGTGACGATGACAGTGATGAGGAAAACTGTGGTTGTAAAGAGAGAGATCTTTGGGAATGTCCATCCAATAAACAATGTTTGAAGCACACAGTGATCTGCGATGGGTTCCCAGACTGCCCTGATTACATGGACGAGAAAAACTGCTCATTTTGCCAAGATGATGAGCTGGAATGTGCAAACCATGCGTGTGTGTCACGTGACCTGTGGTGTGATGGTGAAGCCGACTGCTCAGACAGTTCAGATGAATGGGACTGTGTGACCCTCTCTATAAATGTGAACTCCTCTTCCTTTCTGATGGTTCACAGAGCTGCCACAGAACACCATGTGTGTGCAGATGGCTGGCAGGAGATATTGAGTCAGCTGGCCTGCAAGCAGATGGGTTTAGGAGAACCATCTGTGACCAAATTGATACAGGAACAGGAGAAAGAGCCGCGGTGGCTGACATTACACTCCAACTGGGAGAGCCTCAATGGGACCACTTTACATGAACTTCTAGTAAATGGGCAGTCTTGTGAGAGCAGAAGTAAAATTTCTCTTCTGTGTACTAAACAAGACTGTGGGCGCCGCCCTGCTGCCCGAATGAACAAAAGGATCCTTGGAGGTCGGACGAGTCGCCCTGGAAGGTGGCCATGGCAGTGTTCTCTGCAGAGTGAACCCAGTGGACATATCTGTGGCTGTGTCCTCATTGCCAAGAAGTGGGTTCTGACAGTTGCCCACTGCTTCGAGGGGAGAGAGAATGCTGCAGTTTGGAAAGTGGTGCTTGGCATCAACAATCTAGACCATCCATCAGTGTTCATGCAGACACGCTTTGTGAAGACCATCATCCTGCATCCCCGCTACAGTCGAGCAGTGGTGGACTATGACATCAGCATCGTTGAGCTGAGTGAAGACATCAGTGAGACTGGCTACGTCCGGCCTGTCTGCTTGCCCAACCCGGAGCAGTGGCTAGAGCCTGACACGTACTGCTATATCACAGGCTGGGGCCACATGGGCAATAAAATGCCATTTAAGCTGCAAGAGGGAGAGGTCCGCATTATTTCTCTGGAACATTGTCAGTCCTACTTTGACATGAAGACCATCACCACTCGGATGATATGTGCTGGCTATGAGTCTGGCACAGTTGATTCATGCATGGGTGACAGCGGTGGGCCTCTTGTTTGTGAGAAGCCTGGAGGACGGTGGACATTATTTGGATTAACTTCATGGGGCTCCGTCTGCTTTTCCAAAGTCCTGGGGCCTGGCGTTTATAGTAATGTGTCATATTTCGTCGAATGGATTAAAAGACAGATTTACATCCAGACCTTTCTCCTAAACTAA
Sequence Length
3129
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
113,297 Da
NCBI Official Full Name
Homo sapiens corin, serine peptidase, mRNA
NCBI Official Synonym Full Names
corin, serine peptidase
NCBI Official Symbol
CORIN
NCBI Official Synonym Symbols
CRN; ATC2; Lrp4; PEE5; TMPRSS10
NCBI Protein Information
atrial natriuretic peptide-converting enzyme
UniProt Protein Name
Atrial natriuretic peptide-converting enzyme
Protein Family
UniProt Gene Name
CORIN
UniProt Synonym Gene Names
CRN; TMPRSS10
UniProt Entry Name
CORIN_HUMAN
NCBI Description
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Description
CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.-; Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: plasma membrane
Molecular Function: serine-type endopeptidase activity
Biological Process: female pregnancy; peptide hormone processing; regulation of blood pressure; regulation of systemic arterial blood pressure by atrial natriuretic peptide
Disease: Preeclampsia/eclampsia 5
Research Articles on CORIN
Similar Products
Product Notes
The CORIN corin (Catalog #AAA1266135) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTACC GCAGAGCCGG GTCCCCAAAG CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT GATTGCAATC CCACAACAGA GCATCGCTGC GGGGACGGGC GCTGCATCGC CATGGAGTGG GTGTGTGATG GTGACCACGA CTGTGTGGAT AAGTCCGACG AGGTCAACTG CTCCTGTCAC AGCCAGGGTC TGGTGGAATG CAGAAATGGA CAATGTATCC CCAGCACGTT TCAATGTGAT GGTGACGAGG ACTGCAAGGA TGGGAGTGAT GAGGAGAACT GCAGCGTCAT TCAGACTTCA TGTCAAGAAG GAGACCAAAG ATGCCTCTAC AATCCCTGCC TTGATTCATG TGGTGGTAGC TCTCTCTGTG ACCCGAACAA CAGTCTGAAT AACTGTAGTC AATGTGAACC AATTACATTG GAACTCTGCA TGAATTTGCC CTACAACAGT ACAAGTTATC CAAATTATTT TGGCCACAGG ACTCAAAAGG AAGCATCCAT CAGCTGGGAG TCTTCTCTTT TCCCTGCACT TGTTCAAACC AACTGTTATA AATACCTCAT GTTCTTTTCT TGCACCATTT TGGTACCAAA ATGTGATGTG AATACAGGCG AGCGTATCCC TCCTTGCAGG GCATTGTGTG AACACTCTAA AGAACGCTGT GAGTCTGTTC TTGGGATTGT GGGCCTACAG TGGCCTGAAG ACACAGATTG CAGTCAATTT CCAGAGGAAA ATTCAGACAA TCAAACCTGC CTGATGCCTG ATGAATATGT GGAAGAATGC TCACCTAGTC ATTTCAAGTG CCGCTCAGGA CAGTGTGTTC TGGCTTCCAG AAGATGTGAT GGCCAGGCCG ACTGTGACGA TGACAGTGAT GAGGAAAACT GTGGTTGTAA AGAGAGAGAT CTTTGGGAAT GTCCATCCAA TAAACAATGT TTGAAGCACA CAGTGATCTG CGATGGGTTC CCAGACTGCC CTGATTACAT GGACGAGAAA AACTGCTCAT TTTGCCAAGA TGATGAGCTG GAATGTGCAA ACCATGCGTG TGTGTCACGT GACCTGTGGT GTGATGGTGA AGCCGACTGC TCAGACAGTT CAGATGAATG GGACTGTGTG ACCCTCTCTA TAAATGTGAA CTCCTCTTCC TTTCTGATGG TTCACAGAGC TGCCACAGAA CACCATGTGT GTGCAGATGG CTGGCAGGAG ATATTGAGTC AGCTGGCCTG CAAGCAGATG GGTTTAGGAG AACCATCTGT GACCAAATTG ATACAGGAAC AGGAGAAAGA GCCGCGGTGG CTGACATTAC ACTCCAACTG GGAGAGCCTC AATGGGACCA CTTTACATGA ACTTCTAGTA AATGGGCAGT CTTGTGAGAG CAGAAGTAAA ATTTCTCTTC TGTGTACTAA ACAAGACTGT GGGCGCCGCC CTGCTGCCCG AATGAACAAA AGGATCCTTG GAGGTCGGAC GAGTCGCCCT GGAAGGTGGC CATGGCAGTG TTCTCTGCAG AGTGAACCCA GTGGACATAT CTGTGGCTGT GTCCTCATTG CCAAGAAGTG GGTTCTGACA GTTGCCCACT GCTTCGAGGG GAGAGAGAAT GCTGCAGTTT GGAAAGTGGT GCTTGGCATC AACAATCTAG ACCATCCATC AGTGTTCATG CAGACACGCT TTGTGAAGAC CATCATCCTG CATCCCCGCT ACAGTCGAGC AGTGGTGGAC TATGACATCA GCATCGTTGA GCTGAGTGAA GACATCAGTG AGACTGGCTA CGTCCGGCCT GTCTGCTTGC CCAACCCGGA GCAGTGGCTA GAGCCTGACA CGTACTGCTA TATCACAGGC TGGGGCCACA TGGGCAATAA AATGCCATTT AAGCTGCAAG AGGGAGAGGT CCGCATTATT TCTCTGGAAC ATTGTCAGTC CTACTTTGAC ATGAAGACCA TCACCACTCG GATGATATGT GCTGGCTATG AGTCTGGCAC AGTTGATTCA TGCATGGGTG ACAGCGGTGG GCCTCTTGTT TGTGAGAAGC CTGGAGGACG GTGGACATTA TTTGGATTAA CTTCATGGGG CTCCGTCTGC TTTTCCAAAG TCCTGGGGCC TGGCGTTTAT AGTAATGTGT CATATTTCGT CGAATGGATT AAAAGACAGA TTTACATCCA GACCTTTCTC CTAAACTAA. It is sometimes possible for the material contained within the vial of "CORIN, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
