ELAV-like protein 3 Recombinant Protein | ELAVL3 recombinant protein

Recombinant Human ELAV-like protein 3

Cat. Num. AAA1265333

• Gene Names: ELAVL3; HUC; HUCL; PLE21
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: ELAV-like protein 3; Recombinant Human ELAV-like protein 3; Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21; ELAVL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-367. Full Length
• Sequence: MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for ELAVL3 recombinant protein

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. 1 Publication

Product Categories/Family for ELAVL3 recombinant protein

Developmental Biology

References

Manley T., Furneaux H.M. Isolation of HuC cDNA.Zhang B., Yuan J.G., Qiang B.Q.The DNA sequence and biology of human chromosome 19.Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.Nature 428:529-535(2004) A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.Biochem. Biophys. Res. Commun. 199:1200-1208(1994) RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay.King P.H.Nucleic Acids Res. 28:E20-E20(2000)

NCBI and Uniprot Product Information

• NCBI GI #: 49355761
• NCBI GeneID: 1995
• NCBI Accession #: NP_001411.2
• NCBI GenBank Nucleotide #: NM_001420.3
• UniProt Accession #: Q14576; Q16135; Q96CL8; Q96QS9
• Molecular Weight: 41.5 kDa
• NCBI Official Full Name: ELAV-like protein 3 isoform 1
• NCBI Official Synonym Full Names: ELAV like neuron-specific RNA binding protein 3
• NCBI Official Symbol: ELAVL3
• NCBI Official Synonym Symbols: HUC; HUCL; PLE21
• NCBI Protein Information: ELAV-like protein 3
• UniProt Protein Name: ELAV-like protein 3
• Protein Family: ELAV-like protein
• UniProt Gene Name: ELAVL3
• UniProt Synonym Gene Names: HUC; PLE21; HuC
• UniProt Entry Name: ELAV3_HUMAN

NCBI Description

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.2

Molecular Function: AU-rich element binding; nucleotide binding

Biological Process: cell differentiation; nervous system development