Virion membrane protein A17 precursor (A17L, A18L) Recombinant Protein | A17L recombinant protein
Recombinant Variola virus Virion membrane protein A17 precursor (A17L, A18L)
NCBI and Uniprot Product Information
Uniprot Description
Function: Envelope protein which participates in virus morphogenesis. Needed for an early step in viral crescent membrane formation by interacting with D13 scaffold protein. Its interaction with D13 scaffold protein leads to the formation of rigid, crescent-shaped membranes that assemble around the cytoplasmic virus factory. Membrane anchor for the protein A27. A17-A27 virus envelope protein might be involved in fusion or attachment, and can further associate to A26
By similarity.
Subunit structure: Homodimer; disulfide-linked
Probable. Interacts (via N-terminus) with D13 scaffold; this interaction helps D13 to associate with membranes. Interacts with A14. Interacts with A27; this interaction allows A27 to be anchored in the mature virion (MV) membrane. Part of a complex composed of A17, A25, A26 and A27
By similarity.
Subcellular location: Virion membrane; Multi-pass membrane protein
Potential. Note: The 23 kDa precursor is associated with immature virions (IV) and the final 21 kDa form is present in mature virions (MV)
By similarity.
Post-translational modification: The 23 kDa precursor is cleaved into a final 21 kDa form by the I7 protease during virus maturation
By similarity.Phosphorylated on tyrosine and threonine. Its phosphorylation state is regulated by the F10 kinase and the H1 phosphatase
By similarity. Phosphorylation by F10 kinase seems to be required to form the membranes associated with IV
By similarity.Not glycosylated
By similarity.
Sequence similarities: Belongs to the chordopoxvirinae A17 family.
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Product Notes
The A17L (Catalog #AAA1233941) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 17-185. The amino acid sequence is listed below: AGVLDKDLFT EEQQQSFMPK DGGMMQNDYG GMNDYLGIFK NNDVRTLLGL ILFVLALYSP PLISILMIFI SSFLLPLTSL VITYCLVTQM YRGGNGNTVG MSIVCIVAAV IIMAINVFTN SQIFNIISYI ILFILFFAYV MNIERQDYRR SINVTIPEQY TCNKPYTAG. It is sometimes possible for the material contained within the vial of "Virion membrane protein A17 precursor (A17L, A18L), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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