Sterol regulatory element-binding protein cleavage-activating protein (SCAP) Recombinant Protein | SCAP recombinant protein

Recombinant Cricetulus griseus Sterol regulatory element-binding protein cleavage-activating protein (SCAP), partial

Cat. Num. AAA1213181

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sterol regulatory element-binding protein cleavage-activating protein (SCAP); Recombinant Cricetulus griseus Sterol regulatory element-binding protein cleavage-activating protein (SCAP); partial; SCAP recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,276

• Species: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 345842376
• NCBI GeneID: 100689048
• NCBI Accession #: NP_001230965.1
• NCBI GenBank Nucleotide #: NM_001244036.1
• UniProt Accession #: P97260; Q2WEK9
• Molecular Weight: 139,514 Da
• NCBI Official Full Name: sterol regulatory element-binding protein cleavage-activating protein
• NCBI Official Symbol: Scap
• NCBI Protein Information: sterol regulatory element-binding protein cleavage-activating protein
• UniProt Protein Name: Sterol regulatory element-binding protein cleavage-activating protein
• Protein Family: Sterol regulatory element-binding protein cleavage-activating protein
• UniProt Gene Name: SCAP
• UniProt Synonym Gene Names: SCAP; SREBP cleavage-activating protein

Uniprot Description

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.