Transmembrane O-methyltransferase (LRTOMT) Recombinant Protein | LRTOMT recombinant protein

Recombinant Macaca mulatta Transmembrane O-methyltransferase (LRTOMT)

• Gene Names: LRTOMT; TOMT; COMT2; LRRC51
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transmembrane O-methyltransferase (LRTOMT); Recombinant Macaca mulatta Transmembrane O-methyltransferase (LRTOMT); Recombinant Transmembrane O-methyltransferase (LRTOMT); Transmembrane O-methyltransferase EC= 2.1.1.6; Catechol O-methyltransferase 2 Protein LRTOMT2; LRTOMT recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-296
• Sequence: MGTPWRKRKGIAGPGLPNLSCALVLCLSRSQPRTQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVGTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSHCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIAQALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEEVIPCLRTQYQLSRADLVLLIHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLYHTGLPDFPAIKDGIAQLTYAGPG
• Sequence Length: 296

• Species: Macaca mulatta (Rhesus macaque)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 209870028
• NCBI GeneID: 718286
• NCBI Accession #: NP_001129574.1
• NCBI GenBank Nucleotide #: NM_001136102.1
• UniProt Accession #: B6CZ46; B6CZ47; B6CZ45
• Molecular Weight: 32,666 Da
• NCBI Official Full Name: transmembrane O-methyltransferase isoform 2
• NCBI Official Symbol: LRTOMT
• NCBI Official Synonym Symbols: TOMT; COMT2; LRRC51
• NCBI Protein Information: leucine-rich repeat-containing protein 51; transmembrane O-methyltransferase; Protein LRTOMT1; Protein LRTOMT2; Catechol O-methyltransferase 2; leucine rich repeat containing 51
• UniProt Protein Name: Transmembrane O-methyltransferase
• UniProt Gene Name: LRTOMT
• UniProt Synonym Gene Names: COMT2; TOMT
• UniProt Entry Name: TOMT_MACMU

NCBI Description

This gene encodes two different proteins. One is a leucine-rich transmembrane protein of unknown function while the other is an O-methyltransferase. Defects in the O-methyltransferase protein can cause nonsyndromic deafness in humans. Several transcript variants encoding different isoforms of each protein have been reported for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function

By similarity. UniProtKB Q8WZ04 UniProtKB P21964

Catalytic activity: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. UniProtKB P21964

Subcellular location: Isoform 1: Membrane; Single-pass membrane protein

Potential. Isoform 2: Cytoplasm

By similarity UniProtKB A1Y9I9.

Miscellaneous: In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene. Ref.1

Sequence similarities: Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family.

Sequence caution: The sequence ACF40887.1 differs from that shown. Reason: Frameshift at positions 18 and 31. The sequence ACF40888.1 differs from that shown. Reason: Frameshift at position 11.