WAS protein family homolog 1 (Wash1) Recombinant Protein | Wash1 recombinant protein
Recombinant Rat WAS protein family homolog 1 (Wash1)
NCBI and Uniprot Product Information
Uniprot Description
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
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Product Notes
The Wash1 washc1 (Catalog #AAA1201516) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-475, Full length protein. The amino acid sequence is listed below: MTAVKTQHSL AGQVYAVPLI QPDLRREEAI QQVADALQYL QNISGDIFSR ISQRVELSRR QLQAIGERVS LAQAKIEKIK GSKKAIKVFS SAKYPAPEHL QEYNSVFTGA LDPGLQRRPR YRIQSKHRPL DERALQEKLK YFPVCVSTKS EPEDEAEEGL GGLPSNISSI SSLLLFNTTE NLYKKYVFLD PLAGAVTKTH TMLGTEEEKL FDAPLSISKR EQLEQPAPEN YFYVPGLGQV PEIDVPSYLP DLPGVADDLM YSADLGPGIA PSAPGAIPEL PAFHTEVAEP FQPEREDGAL LAPPPPPPPP PPPPPPAPTA VVSAPQPPMS PDVVTVTGKV AREEDSGSGE AHSASVQGAP KEVVDPSSGR ATLLESIRQA GGIGKAKLRS VKERKLEKKK QKEQEQVRAT SQGGDLMSDL FNKLVMRRKG ISGKGPGTGT SEGPGGAFSR MSDSIPPLPP PQQPAGDEDE DDWES. It is sometimes possible for the material contained within the vial of "WAS protein family homolog 1 (Wash1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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