ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1) Recombinant Protein | hrd1 recombinant protein
Recombinant Schizosaccharomyces pombe ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1); Recombinant Schizosaccharomyces pombe ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1); Recombinant ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1); ERAD-associated E3 ubiquitin-protein ligase hrd1 EC= 6.3.2.-; hrd1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-677
Sequence
MKFILYVLASLVLFGLSVLLSLYSSANVYSATVMISQSPVHITIGLNVCLCLFFAIANALKTLLFGSLQTFELELLYEQFWITLTEIMLAITVFREAISISFFMLLSTLMFARVFHSICSFRTERLQIQLTDQRFHIFSRLTCAYFVLSILDASLIYLCFTSEHLGDKSTRMLFVCEFSVLLLNLTIEASKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFYSLFRRIREHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPLPRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSVIGNQSSPTGIPASPNVRATQIATQVPNPQNTPTTTAVPGITNSSNQGDPQASTFNGVPNANSSGFAAHTQDLSSVIPRRIALRDGWTMLPIPGTRRIPTYSQSTSTTNPSATPTTGDPSNSTYGGPQTFPNSGNNPNFNRGIAGIVPPGWRLVSSNTQSLSTNSAMTSLYQNASSADNNLGSSLPNVVPLSRGLTQSNETSNTFPAASSNISSQLRELHTKIDELRETVSNFRADYNSIRTSLNQLEAASGINERIQTTSADSLLNSNGMSGTEGFENTQTSITTNDNQSSILTSSDQTSPFATDEDRQNSRNVQLETVDENF
Sequence Length
677
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
75,657 Da
NCBI Official Full Name
ubiquitin-protein ligase Hrd1, synviolin family
NCBI Official Symbol
hrd1
NCBI Protein Information
ubiquitin-protein ligase Hrd1, synviolin family
UniProt Protein Name
ERAD-associated E3 ubiquitin-protein ligase hrd1
Protein Family
UniProt Gene Name
hrd1
UniProt Entry Name
HRD1_SCHPO
Uniprot Description
Function: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M)
By similarity. Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1. Ref.3
Pathway: Protein modification; protein ubiquitination.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Potential.
Sequence similarities: Belongs to the HRD1 family.Contains 1 RING-type zinc finger.
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Product Notes
The hrd1 hrd1 (Catalog #AAA1193822) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-677. The amino acid sequence is listed below: MKFILYVLAS LVLFGLSVLL SLYSSANVYS ATVMISQSPV HITIGLNVCL CLFFAIANAL KTLLFGSLQT FELELLYEQF WITLTEIMLA ITVFREAISI SFFMLLSTLM FARVFHSICS FRTERLQIQL TDQRFHIFSR LTCAYFVLSI LDASLIYLCF TSEHLGDKST RMLFVCEFSV LLLNLTIEAS KLCIYLYEAR HLDQVWDEKS TYLFRLEVCR DGLRLLAYSL LFMYQFPYVS VPIYSIRQMY TCFYSLFRRI REHARFRQAT RDMNAMYPTA TEEQLTNSDR TCTICREEMF HPDHPPENTD EMEPLPRGLD MTPKRLPCGH ILHFHCLRNW LERQQTCPIC RRSVIGNQSS PTGIPASPNV RATQIATQVP NPQNTPTTTA VPGITNSSNQ GDPQASTFNG VPNANSSGFA AHTQDLSSVI PRRIALRDGW TMLPIPGTRR IPTYSQSTST TNPSATPTTG DPSNSTYGGP QTFPNSGNNP NFNRGIAGIV PPGWRLVSSN TQSLSTNSAM TSLYQNASSA DNNLGSSLPN VVPLSRGLTQ SNETSNTFPA ASSNISSQLR ELHTKIDELR ETVSNFRADY NSIRTSLNQL EAASGINERI QTTSADSLLN SNGMSGTEGF ENTQTSITTN DNQSSILTSS DQTSPFATDE DRQNSRNVQL ETVDENF. It is sometimes possible for the material contained within the vial of "ERAD-associated E3 ubiquitin-protein ligase hrd1 (hrd1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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