Epstein-Barr nuclear antigen 2 (EBNA2) Recombinant Protein | EBNA2BYRF1 recombinant protein
Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2 (EBNA2)
NCBI and Uniprot Product Information
Uniprot Description
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.
Research Articles on EBNA2BYRF1
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Product Notes
The EBNA2BYRF1 ebna2 (Catalog #AAA1180742) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 320-487aa; Partial. The amino acid sequence is listed below: GPPWWPPICD PPQPSKTQGQ SRGQSRGRGR GRGRGRGKGK SRDKQRKPGG PWRPEPNTSS PSMPELSPVL GLHQGQGAGD SPTPGPSNAA PVCRNSHTAT PNVSPIHEPE SHNSPEAPIL FPDDWYPPSI DPADLDESWD YIFETTESPS SDEDYVEGPS KRPRPSIQ . It is sometimes possible for the material contained within the vial of "Epstein-Barr nuclear antigen 2 (EBNA2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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