SDS-PAGE
Desmoglein-2 (Dsg2) Recombinant Protein | Dsg2 recombinant protein
Recombinant Mouse Desmoglein-2 (Dsg2)
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
Uniprot Description
DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Cell adhesion; Membrane protein, integral; Calcium-binding
Cellular Component: desmosome; cell surface; membrane; apical plasma membrane; plasma membrane; integral to membrane; cell junction; lateral plasma membrane
Molecular Function: metal ion binding; calcium ion binding
Biological Process: cell adhesion; homophilic cell adhesion
Research Articles on Dsg2
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Product Notes
The Dsg2 dsg2 (Catalog #AAA1133982) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 55-618aa; Extracellular Domain. The amino acid sequence is listed below: AWITAPVALR EGEDLSRKNP IAKIHSDLAE EKGIKITYKY TGKGITEPPF GIFVFDRNTG ELNITSILDR EETPYFLLTG YALDSRGNNL EKPLELRIKV LDINDNEPVF TQEVFVGSIE ELSAAHTLVM KITATDADDP ETLNAKVSYR IVSQEPANSH MFYLNKDTGE IYTTSFTLDR EEHSSYSLTV EARDGNGQIT DKPVQQAQVQ IRILDVNDNI PVVENKMYEG TVEENQVNVE VMRIKVTDAD EVGSDNWLAN FTFASGNEGG YFHIETDTQT NEGIVTLVKE VDYEEMKKLD LSIIVTNKAA FHKSILSKYK ATPIPITVKV KNVVEGIHFK SSVVSFRASE AMDRSSLSRS IGNFQVFDED TGQAAKVTYV KVQDTDNWVS VDSVTSEIKL VKIPDFESRY VQNGTYTAKV VAISKEHPQK TITGTIVITV EDVNDNCPVL VDSVRSVCED EPYVNVTAED LDGAQNSAPF SFSIIDQPPG TAQKWKITHQ ESTSVLLQQS ERKRGRSEIP FLISDSQGFS CPERQVLQLT VCECLKGGGC VAAQYDNYVG LGPA. It is sometimes possible for the material contained within the vial of "Desmoglein-2 (Dsg2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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