Spastin (spas) Recombinant Protein | DsimGD21056 recombinant protein
Recombinant Drosophila simulans Spastin (spas)
NCBI and Uniprot Product Information
Uniprot Description
Function: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse
By similarity. HAMAP-Rule MF_03021
Catalytic activity: ATP + H2O = ADP + phosphate. HAMAP-Rule MF_03021
Subunit structure: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules
By similarity.
Subcellular location: Membrane; Single-pass membrane protein
Potential. Cytoplasm › cytoskeleton › centrosome
By similarity. Cytoplasm › cytoskeleton
By similarity. Chromosome
By similarity. Note: Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules. Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles
By similarity. HAMAP-Rule MF_03021
Sequence similarities: Belongs to the AAA ATPase family. Spastin subfamily.Contains 1 MIT domain.
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Product Notes
The DsimGD21056 spas (Catalog #AAA1131612) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-758. The amino acid sequence is listed below: MVRTKNQSSS SSASSSSTKS PIKSSSGAGS SGGGVGGRQS THRSSSASNV AAVVAGGSSA AGGGSSSNRR SPGSSPDGDD DTTTTDDLTP TTCSPRSGHH HSYGGYSSSV HKQNLYVVSF PIIFLFNVLR SLIYQLFCIF RYLYGASTKV IYRPHRRDCN IEIVVQNSSK EQQQSLNHPS ELNREGDGQE QQLSNQPQRF RPIQPLEMAA NRPGGGYSPG PGDPLLAKQK HHHRRAFEYI SKALKIDEEN EGHKELAIEL YRKGIKELED GIAVDCWSGR GDVWDRAQRL HDKMQTNLSM ARDRLHFLAL REQDLQMQRL SLKEKQKEEA RSKPQKSREP MLAGMTNEPM KLRVRSSGYG PKATTSAQPT ASGRKLTIGS KRPVNLAVAN KSQTLPRNLG SKTSVGAVQR QPAKTAATPP AVRRQFSSGR NTPPQRSRTP INNNGPSGSG ASTPVVSVKG VEQKLVQLIL DEIVEGGAKV EWTDIAGQDV AKQALQEMVI LPSVRPELFT GLRAPAKGLL LFGPPGNGKT LLARAVATEC SATFLNISAA SLTSKYVGDG EKLVRALFAV ARHMQPSIIF IDEVDSLLSE RSSSEHEASR RLKTEFLVEF DGLPGNPDGD RIVVLAATNR PQELDEAALR RFTKRVYVSL PDEQTRELLL NRLLQKQGSP LDTEALRRLA KITDGYSGSD LTARPKDAAL EPIRELNVEQ VKCLDISAMR AITEQDFHSS LKRIRRSVAP QSLNSYEKWS QDYGDITI. It is sometimes possible for the material contained within the vial of "Spastin (spas), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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