Furin-like protease 1, isoform 1-CRR (Fur1) Recombinant Protein | Fur1 recombinant protein

Recombinant Drosophila melanogaster Furin-like protease 1, isoform 1-CRR (Fur1)

• Gene Names: Fur1; CG10772; dFur1; Dfur1; dFurin 1; Dfurin1; dKLIP-1; DmelCG10772; fur-1; fur1; furin; Furin; Furl; fur[1]; Klip1; l(3)rL205
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Furin-like protease 1; isoform 1-CRR (Fur1); Recombinant Drosophila melanogaster Furin-like protease 1; Recombinant Furin-like protease 1; isoform 1-CRR; Furin-1 EC= 3.4.21.75; Kex2-like endoprotease 1 dKLIP-1; Fur1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 310-1101
• Sequence: DFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDPLQAEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFCYAYVVRSTGMASVVDISKMDDRDTQQYMTGTTVLLLVSVIFTLMGVAVAGGIVYHRRAMARSNELYSRVSLVPGDESDSDEDELFTAHFPARKSGVNIYRDEAPSEKIFEEDEISHLVP
• Sequence Length: 1101

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 24650056
• NCBI GeneID: 47220
• NCBI Accession #: NP_733102.1
• NCBI GenBank Nucleotide #: NM_170654.1
• UniProt Accession #: P30430; Q27235; Q9VBR5; AAA28545
• Molecular Weight: 120,993 Da
• NCBI Official Full Name: furin 1, isoform A
• NCBI Official Synonym Full Names: Furin 1
• NCBI Official Symbol: Fur1
• NCBI Official Synonym Symbols: CG10772; dFur1; Dfur1; dFurin 1; Dfurin1; dKLIP-1; DmelCG10772; fur-1; fur1; furin; Furin; Furl; fur[1]; Klip1; l(3)rL205
• NCBI Protein Information: CG10772 gene product from transcript CG10772-RA; CG10772-PA; CG10772-PB; CG10772-PC; CG10772-PD; CG10772-PE; CG10772-PF; Dfurin1; Fur1-PA; Fur1-PB; Fur1-PC; Fur1-PD; Fur1-PE; Fur1-PF; Furin-like protease; furin 1
• UniProt Protein Name: Furin-like protease 1, isoform 1-CRR
• Protein Family: Furin-like protease
• UniProt Gene Name: Fur1
• UniProt Synonym Gene Names: Furin-1
• UniProt Entry Name: FUR1C_DROME

Uniprot Description

Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif

By similarity.

Catalytic activity: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors.

Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein Ref.2.

Tissue specificity: In adults, isoform 1-CRR is expressed in CNS, fat body, and female reproductive tissues, and in embryos, in anal pads, hindgut, developing antennomaxillary complex, oenocytes, clipeolabrum, pharynx, trachea, CNS and developing posterior spiracles. Ref.2

Developmental stage: Isoform 1-CRR is expressed in embryos, larvae, pupae and adults. Ref.2

Sequence similarities: Belongs to the peptidase S8 family. Furin subfamily.