Deubiquitinase and deneddylase Dub1 (cdu1) Recombinant Protein | CTL0247 recombinant protein
Recombinant Chlamydia trachomatis serovar L2 Deubiquitinase and deneddylase Dub1 (cdu1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities
By similarity. Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation. Ref.2
Subunit structure: Binds to host NFKBIA. Ref.2
Subcellular location: Secreted. Host cell. Membrane; Single-pass membrane protein. Note: Secreted, and delivered into the host cell. Located predominantly on the plasma membrane and to a lesser extent on intracellular membranes, especially the host cell nuclear envelope. Ref.2
Induction: Expressed late in the infectious cycle. Ref.2
Sequence similarities: Belongs to the peptidase C48 family.
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Product Notes
The CTL0247 cdu1 (Catalog #AAA1114864) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-401. The amino acid sequence is listed below: MLSPTNSTSK TAPVPPRDSS KPVLISEEPR NQLLQKVART ALAVLLVVVT LGLILLFYSF SDLQSFPWCC QTHPSTKEQP TISIPVPLPS PPLAVPRPST PPPPVISRPS TPSAPKPSTP PPLLPKAPKP VKTQEDLLPL VPEQVFVEMY EDMARRQTIE ALVPAWDSDI IFKCLCYFHT LYPGLIPLET FPPATIFNFK QKIISILEDK KAVLRGEPIK GPLPICCSKE NYRRHLQRTT LLPVFMWYHP TPKTLSDTMQ TMKQLAIKGS VGASHWLLVI VDIQARRLVY FDSLYNYVMP PENMKKELQS FAQQLDQVYP AYDSKKFSVK IAAKEVIQRG SGSSCGAWCC QFLHWYLKDP LTDALNDLPV DSVERHENLA SFVQACEAAV QDLPELSWPE A. It is sometimes possible for the material contained within the vial of "Deubiquitinase and deneddylase Dub1 (cdu1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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