Chemokine-binding protein 2 (CCBP2) Recombinant Protein | CCBP2 recombinant protein

Recombinant Human Chemokine-binding protein 2 (CCBP2)

• Gene Names: CCBP2; D6; hD6; CCR9; CCR10; CMKBR9
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Chemokine-binding protein 2 (CCBP2); Recombinant Human Chemokine-binding protein 2 (CCBP2); Recombinant Chemokine-binding protein 2 (CCBP2); Chemokine-binding protein 2; C-C chemokine receptor D6 Chemokine receptor CCR-10 Chemokine receptor CCR-9 Chemokine-binding protein D6; CCBP2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-384
• Sequence: MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA
• Sequence Length: 384

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 13929467
• NCBI GeneID: 1238
• NCBI Accession #: NP_001287.2
• NCBI GenBank Nucleotide #: NM_001296.4
• UniProt Accession #: O00590; O00537; Q53YA1; Q86UN9; Q96A02; B2R8Y8
• Molecular Weight: 43,443 Da
• NCBI Official Full Name: chemokine-binding protein 2
• NCBI Official Synonym Full Names: chemokine binding protein 2
• NCBI Official Symbol: CCBP2
• NCBI Official Synonym Symbols: D6; hD6; CCR9; CCR10; CMKBR9
• NCBI Protein Information: chemokine-binding protein 2; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61
• UniProt Protein Name: Chemokine-binding protein 2
• UniProt Gene Name: CCBP2
• UniProt Synonym Gene Names: CCR10; CMKBR9
• UniProt Entry Name: CCBP2_HUMAN

NCBI Description

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Uniprot Description

CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response