Frizzled (fz) Recombinant Protein | fz recombinant protein
Recombinant Drosophila melanogaster Frizzled (fz)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway
By similarity.The FZ domain is involved in binding with Wnt ligands
By similarity.
Sequence similarities: Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.
Research Articles on fz
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Product Notes
The fz fz (Catalog #AAA1083421) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-581. The amino acid sequence is listed below: YDQSPLDASP YYRSGGGLMA SSGTELDGLP HHNRCEPITI SICKNIPYNM TIMPNLIGHT KQEEAGLEVH QFAPLVKIGC SDDLQLFLCS LYVPVCTILE RPIPPCRSLC ESARVCEKLM KTYNFNWPEN LECSKFPVHG GEDLCVAENT TSSASTAATP TRSVAKVTTR KHQTGVESPH RNIGFVCPVQ LKTPLGMGYE LKVGGKDLHD CGAPCHAMFF PERERTVLRY WVGSWAAVCV ASCLFTVLTF LIDSSRFRYP ERAIVFLAVC YLVVGCAYVA GLGAGDSVSC REPFPPPVKL GRLQMMSTIT QGHRQTTSCT VLFMALYFCC MAAFAWWSCL AFAWFLAAGL KWGHEAIENK SHLFHLVAWA VPALQTISVL ALAKVEGDIL SGVCFVGQLD THSLGAFLIL PLCIYLSIGA LFLLAGFISL FRIRTVMKTD GKRTDKLERL MLRIGFFSGL FILPAVGLLG CLFYEYYNFD EWMIQWHRDI CKPFSIPCPA ARAPGSPEAR PIFQIFMVKY LCSMLVGVTS SVWLYSSKTM VSWRNFVERL QGKEPRTRAQ AYV. It is sometimes possible for the material contained within the vial of "Frizzled (fz), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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