Lysosomal alpha-mannosidase (MAN2B1) Recombinant Protein | MAN2B1 recombinant protein

Recombinant Human Lysosomal alpha-mannosidase (MAN2B1) , partial

• Gene Names: MAN2B1; MANB; LAMAN
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lysosomal alpha-mannosidase (MAN2B1); Recombinant Human Lysosomal alpha-mannosidase (MAN2B1); partial; MAN2B1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1011

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MAN2B1 recombinant protein

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13
15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis.

NCBI and Uniprot Product Information

• NCBI GI #: 51873064
• NCBI GeneID: 4125
• NCBI Accession #: NP_000519.2
• NCBI GenBank Nucleotide #: NM_000528.3
• UniProt Accession #: O00754; O15330; Q16680; Q93094; Q9BW13; G5E928
• Molecular Weight: 113,616 Da
• NCBI Official Full Name: lysosomal alpha-mannosidase isoform 1
• NCBI Official Synonym Full Names: mannosidase alpha class 2B member 1
• NCBI Official Symbol: MAN2B1
• NCBI Official Synonym Symbols: MANB; LAMAN
• NCBI Protein Information: lysosomal alpha-mannosidase
• UniProt Protein Name: Lysosomal alpha-mannosidase
• UniProt Gene Name: MAN2B1
• UniProt Synonym Gene Names: LAMAN; MANB; Laman

NCBI Description

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Uniprot Description

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.