Histone lysine demethylase PHF8 (phf8) Recombinant Protein | phf8 recombinant protein

Recombinant Danio rerio Histone lysine demethylase PHF8 (phf8), partial

• Gene Names: phf8; zPHF8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Histone lysine demethylase PHF8 (phf8); Recombinant Danio rerio Histone lysine demethylase PHF8 (phf8); partial; phf8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,032

• Species: Zebrafish
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 320461531
• NCBI GeneID: 566534
• NCBI Accession #: NP_001189376.1
• NCBI GenBank Nucleotide #: NM_001202447.1
• UniProt Accession #: P0CH95
• Molecular Weight: 114,222 Da
• NCBI Official Full Name: histone lysine demethylase PHF8
• NCBI Official Synonym Full Names: PHD finger protein 8
• NCBI Official Symbol: phf8
• NCBI Official Synonym Symbols: zPHF8
• NCBI Protein Information: histone lysine demethylase PHF8
• UniProt Protein Name: Histone lysine demethylase PHF8
• Protein Family: Histone lysine demethylase
• UniProt Gene Name: phf8
• UniProt Synonym Gene Names: zPHF8

Uniprot Description

Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (). Required for brain development, probably by regulating expression of neuron-specific genes.