Sorbin and SH3 domain-containing protein 2 (SORBS2) Recombinant Protein | SORBS2 recombinant protein

Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2) , partial

Cat. Num. AAA1057318

• Gene Names: SORBS2; ARGBP2; PRO0618
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sorbin and SH3 domain-containing protein 2 (SORBS2); Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2); partial; SORBS2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 731

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SORBS2 recombinant protein

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg
Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 224586844
• NCBI GeneID: 8470
• NCBI Accession #: NP_001139142.1
• NCBI GenBank Nucleotide #: NM_001145670.1
• UniProt Accession #: O94875; A6NEK9; B3KPQ7; B7Z1G5; B7Z3X6; C9JKV9; D3DP62; D3DP63; E9PAS5; E9PAW4; G3XAI0; H7BXR4
• Molecular Weight: 80,966 Da
• NCBI Official Full Name: sorbin and SH3 domain-containing protein 2 isoform 3
• NCBI Official Synonym Full Names: sorbin and SH3 domain containing 2
• NCBI Official Symbol: SORBS2
• NCBI Official Synonym Symbols: ARGBP2; PRO0618
• NCBI Protein Information: sorbin and SH3 domain-containing protein 2
• UniProt Protein Name: Sorbin and SH3 domain-containing protein 2
• Protein Family: Sorbin and SH3 domain-containing protein
• UniProt Gene Name: SORBS2
• UniProt Synonym Gene Names: ARGBP2; KIAA0777; ArgBP2

NCBI Description

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.