Beta/omega-theraphotoxin-Tp2a Recombinant Protein | Beta/omega-TRTX-Tp2a recombinant protein
Recombinant Thrixopelma pruriens Beta/omega-theraphotoxin-Tp2a
NCBI and Uniprot Product Information
Uniprot Description
Function: Blocks both tetrodotoxin-sensitive and tetrodotoxin-resistant human voltage-gated sodium channels by shifting the voltage dependence of channel activation to more positive potentials. Inhibits Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.7/SCN9A, Nav1.8/SCN10A. Is significantly more potent against Nav1.7/SCN9A than the other Nav channel subtypes. Has no significant effect on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, and Kv2.1/KCNB1 channels. Also inhibits Cav1.2/CACNA1C and Cav3.1/CACNA1G channels with an IC50 around 100 nM. Does not bind to the pharmacologically defined Nav channel sites 3 or 4. Neutralization of gating charges in the voltage sensor (S4) of domain II of Nav1.2/SCN2A prevents the effect of the toxin on gating current. Thus, it has been suggested that the toxin acts by trapping the voltage sensor of Nav channel domain II in the resting state, impeding outward gating movement of the IIS4 transmembrane segment of the channel. Binds to phospholipids. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location: Secreted Ref.1.
Tissue specificity: Expressed by the venom gland. Ref.1
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Sequence similarities: Belongs to the phrixotoxin family.
Mass spectrometry: Molecular mass is 3827 Da from positions 1 - 30. Determined by ESI. Ref.1Molecular mass is 3827 Da from positions 1 - 30. Determined by MALDI. Ref.1
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Product Notes
The Beta/omega-theraphotoxin-Tp2a beta/omega-trtx-tp2a (Catalog #AAA1044147) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30aa; Cytoplasmic domain. The amino acid sequence is listed below: YCQKWMWTCD SERKCCEGMV CRLWCKKKLW. It is sometimes possible for the material contained within the vial of "Beta/omega-theraphotoxin-Tp2a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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