Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) Recombinant Protein | RECK recombinant protein

Recombinant Human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) , partial

• Gene Names: RECK; ST15
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Reversion-inducing cysteine-rich protein with Kazal motifs (RECK); Recombinant Human Reversion-inducing cysteine-rich protein with Kazal motifs (RECK); partial; RECK recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 971

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RECK recombinant protein

This protein is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.

NCBI and Uniprot Product Information

• NCBI GI #: 11863156
• NCBI GeneID: 8434
• NCBI Accession #: NP_066934.1
• NCBI GenBank Nucleotide #: NM_021111.2
• UniProt Accession #: O95980; Q5W0K6; Q8WX37; B2RNS1
• Molecular Weight: 106,457 Da
• NCBI Official Full Name: reversion-inducing cysteine-rich protein with Kazal motifs isoform 1
• NCBI Official Synonym Full Names: reversion inducing cysteine rich protein with kazal motifs
• NCBI Official Symbol: RECK
• NCBI Official Synonym Symbols: ST15
• NCBI Protein Information: reversion-inducing cysteine-rich protein with Kazal motifs
• UniProt Protein Name: Reversion-inducing cysteine-rich protein with Kazal motifs
• Protein Family: Reversion-inducing cysteine-rich protein
• UniProt Gene Name: RECK
• UniProt Synonym Gene Names: ST15; hRECK

NCBI Description

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.