ZNF259 Blocking Peptide | ZPR1 blocking peptide

ZNF259 Antibody (C-term) Blocking Peptide

• Gene Names: ZPR1; ZNF259
• Synonyms: ZNF259; ZNF259 Antibody (C-term) Blocking Peptide; Zinc finger protein ZPR1; Zinc finger protein 259; ZPR1; ZPR1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 459

• Cellular Location: Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm Cell projection, axon. Cell projection, growth cone. Note: Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum- starved cells growth arrested in G0 of the mitotic cell cycle Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner.
• Tissue Location: Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZPR1 blocking peptide

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.

NCBI and Uniprot Product Information

• NCBI GI #: 6137318
• NCBI GeneID: 8882
• UniProt Accession #: O75312; Q2TAA0
• Molecular Weight: 50,925 Da
• NCBI Official Full Name: Zinc finger protein ZPR1
• NCBI Official Synonym Full Names: ZPR1 zinc finger
• NCBI Official Symbol: ZPR1
• NCBI Official Synonym Symbols: ZNF259
• NCBI Protein Information: zinc finger protein ZPR1
• UniProt Protein Name: Zinc finger protein ZPR1
• Protein Family: Zinc finger protein
• UniProt Gene Name: ZPR1
• UniProt Synonym Gene Names: ZNF259
• UniProt Entry Name: ZPR1_HUMAN

NCBI Description

The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

ZNF259: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Belongs to the ZPR1 family.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: axon; Cajal body; cell soma; cytoplasm; growth cone; nucleolus; nucleoplasm; nucleus; perikaryon; SMN complex

Molecular Function: protein binding; translation initiation factor binding

Biological Process: Cajal body organization and biogenesis; cell proliferation; DNA endoreduplication; microtubule cytoskeleton organization and biogenesis; positive regulation of growth; positive regulation of protein import into nucleus; positive regulation of RNA splicing; regulation of myelination; signal transduction; spinal cord development; trophectodermal cell proliferation