Lead, cadmium, zinc and mercury-transporting ATPase (zntA) Recombinant Protein | zntA recombinant protein

Recombinant Escherichia coli Lead, cadmium, zinc and mercury-transporting ATPase (zntA)

Gene Names

zntA; ECK3453; JW3434; yhhO

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Synonyms

Lead; cadmium; zinc and mercury-transporting ATPase (zntA); Recombinant Escherichia coli Lead; Recombinant Lead; zinc and mercury-transporting ATPase EC= 3.6.3.3 EC= 3.6.3.5; zntA recombinant protein

Ordering

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE.

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Sequence Positions

1-732

Sequence

MSTPDNHGKKAPQFAAFKPLTTVQNANDCCCDGACSSTPTLSENVSGTRYSWKVSGMDCAACARKVENAVRQLAGVNQVQVLFATEKLVVDADNDIRAQVESALQKAGYSLRDEQAAEEPQASRLKENLPLITLIVMMAISWGLEQFNHPFGQLAFIATTLVGLYPIARQALRLIKSGSYFAIETLMSVAAIGALFIGATAEAAMVLLLFLIGERLEGWAASRARQGVSALMALKPETATRLRKGEREEVAINSLRPGDVIEVAAGGRLPADGKLLSPFASFDESALTGESIPVERATGDKVPAGATSVDRLVTLEVLSEPGASAIDRILKLIEEAEERRAPIERFIDRFSRIYTPAIMAVALLVTLVPPLLFAASWQEWIYKGLTLLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTQVAFDKTGTLTVGKPRVTAIHPATGISESELLTLAAAVEQGATHPLAQAIVREAQVAELAIPTAESQRALVGSGIEAQVNGERVLICAAGKHPADAFTGLINELESAGQTVVLVVRNDDVLGVIALQDTLRADAATAISELNALGVKGVILTGDNPRAAAAIAGELGLEFKAGLLPEDKVKAVTELNQHAPLAMVGDGINDAPAMKAAAIGIAMGSGTDVALETADAALTHNHLRGLVQMIELARATHANIRQNITIALGLKGIFLVTTLLGMTGLWLAVLADTGATVLVTANALRLLRRR

Sequence Length

732

Species

Escherichia coli (strain K12)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

NCBI GI #

16131341

NCBI GeneID

947972

NCBI Accession #

NP_417926.1

NCBI GenBank Nucleotide #

NC_000913.2

UniProt Accession #

P37617; Q2M7D2

Molecular Weight

76,840 Da

NCBI Official Full Name

zinc, cobalt and lead efflux system

NCBI Official Symbol

zntA

NCBI Official Synonym Symbols

ECK3453; JW3434; yhhO

NCBI Protein Information

zinc, cobalt and lead efflux system

UniProt Protein Name

Lead, cadmium, zinc and mercury-transporting ATPase

Protein Family

Lead, cadmium, zinc and mercury-transporting ATPase

UniProt Gene Name

zntA

UniProt Synonym Gene Names

yhhO

UniProt Entry Name

ATZN_ECOLI

NCBI Description

HAD superfamily. [More information is available at EcoGene: EG12215]. The gene product of the yhhO gene, also referred to as zntA, is a P-type ATPase involved in the efflux of Pb(II), Cd(II), and Zn(II) . [More information is available at EcoCyc: EG12215].

Uniprot Description

Function: Involved in export of lead, cadmium, zinc and mercury.

Catalytic activity: ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Subcellular location: Cell inner membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]Contains 1 HMA domain.

Research Articles on zntA

1. Data suggest that a kinetically-controlled transcription model is sufficient to explain the observed regulation of intracellular free zinc concentration by ZntR and ZntA after zinc shock.

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Product Notes

The zntA znta (Catalog #AAA1113338) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-732. The amino acid sequence is listed below: MSTPDNHGKK APQFAAFKPL TTVQNANDCC CDGACSSTPT LSENVSGTRY SWKVSGMDCA ACARKVENAV RQLAGVNQVQ VLFATEKLVV DADNDIRAQV ESALQKAGYS LRDEQAAEEP QASRLKENLP LITLIVMMAI SWGLEQFNHP FGQLAFIATT LVGLYPIARQ ALRLIKSGSY FAIETLMSVA AIGALFIGAT AEAAMVLLLF LIGERLEGWA ASRARQGVSA LMALKPETAT RLRKGEREEV AINSLRPGDV IEVAAGGRLP ADGKLLSPFA SFDESALTGE SIPVERATGD KVPAGATSVD RLVTLEVLSE PGASAIDRIL KLIEEAEERR APIERFIDRF SRIYTPAIMA VALLVTLVPP LLFAASWQEW IYKGLTLLLI GCPCALVIST PAAITSGLAA AARRGALIKG GAALEQLGRV TQVAFDKTGT LTVGKPRVTA IHPATGISES ELLTLAAAVE QGATHPLAQA IVREAQVAEL AIPTAESQRA LVGSGIEAQV NGERVLICAA GKHPADAFTG LINELESAGQ TVVLVVRNDD VLGVIALQDT LRADAATAIS ELNALGVKGV ILTGDNPRAA AAIAGELGLE FKAGLLPEDK VKAVTELNQH APLAMVGDGI NDAPAMKAAA IGIAMGSGTD VALETADAAL THNHLRGLVQ MIELARATHA NIRQNITIAL GLKGIFLVTT LLGMTGLWLA VLADTGATVL VTANALRLLR RR. It is sometimes possible for the material contained within the vial of "Lead, cadmium, zinc and mercury-transporting ATPase (zntA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

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