Mouse Zic family member 3 (odd-paired homolog, Drosophila) ELISA Kit | ZIC3 elisa kit
Mouse Zinc finger protein ZIC 3, ZIC3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ZIC3: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Defects in ZIC3 are the cause of visceral heterotaxy X- linked type 1 (HTX1). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy X- linked type 1 include dextrocardia, corrected transposition of great arteries, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis, situs inversus viscerum, and asplenia and/or polysplenia. Defects in ZIC3 are a cause of VACTERL association X- linked with or without hydrocephalus (VACTERLX). A syndrome characterized by vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; nucleic acid binding; DNA binding; sequence-specific DNA binding; metal ion binding; transcription factor activity
Biological Process: anterior/posterior pattern formation; transcription from RNA polymerase II promoter; nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; heart looping; cell differentiation; determination of left/right symmetry; pattern specification process; lung development
Research Articles on ZIC3
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Product Notes
The Mouse ZIC3 zic3 (Catalog #AAA9318677) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318677 ELISA Kit recognizes Mouse ZIC3. It is sometimes possible for the material contained within the vial of "Zic family member 3 (odd-paired homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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