Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (yheH) Recombinant Protein | yheH recombinant protein
Recombinant Bacillus subtilis Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (yheH)
NCBI and Uniprot Product Information
Uniprot Description
Function: Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Ref.4
Enzyme regulation: Inhibited by ortho-vanadate. Ref.4
Subunit structure: Heterodimer composed of YheH and YheI. Ref.4
Subcellular location: Cell membrane; Multi-pass membrane protein Ref.4.
Induction: Induced by several classes of structurally unrelated antibiotics, such as erythromycin, fusidic acid or linezolid. Ref.4
Miscellaneous: Overexpression reduces the sporulation efficiency possibly by modulating the function of KinA.
Sequence similarities: Belongs to the ABC transporter superfamily.Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.
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Product Notes
The yheH yheh (Catalog #AAA1166784) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-673. The amino acid sequence is listed below: MKIGKTLWRY ALLYRKLLIT AVLLLTVAVG AELTGPFIGK KMIDDHILGI EKTWYEAAEK DKNAVQFHGV SYVREDRLQE PVSKAKEAHI YQVGMAFYFV DQAVSFDGNR TVSDGKLTIT NGDKSRAYAA EKLTKQELFQ FYQPEIKGMV LLICLYGGLL VFSVFFQYGQ HYLLQMSANR IIQKMRQDVF SHIQKMPIRY FDNLPAGKVV ARITNDTEAI RDLYVTVLST FVTSGIYMFG IFTALFLLDV KLAFVCLAIV PIIWLWSVIY RRYASYYNQK IRSINSDINA KMNESIQGMT IIQAFRHQKE TMREFEELNE SHFYFQNRML NLNSLMSHNL VNVIRNLAFV CLIWHFGGAS LNAAGIVSIG VLYAFVDYLN RLFQPITGIV NQFSKLELAR VSAGRVFELL EEKNTEEAGE PAKERALGRV EFRDVSFAYQ EGEEVLKHIS FTAQKGETVA LVGHTGSGKS SILNLLFRFY DAQKGDVLID GKSIYNMSRQ ELRSHMGIVL QDPYLFSGTI GSNVSLDDER MTEEEIKNAL RQVGAEPLLK KLPKGINEPV IEKGSTLSSG ERQLISFARA LAFDPAILIL DEATAHIDTE TEAVIQKALD VVKQGRTTFV IAHRLSTIRN ADQILVLDKG EIVERGNHEE LMALEGQYYQ MYELQKGQKH SIA. It is sometimes possible for the material contained within the vial of "Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (yheH), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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