Mouse X-ray repair complementing defective repair in Chinese hamster cells 4 ELISA Kit | XRCC4 elisa kit
Mouse DNA repair protein XRCC4, XRCC4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
XRCC4: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Widely expressed. Belongs to the XRCC4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; DNA ligase IV complex; centrosome; DNA-dependent protein kinase complex; cytosol; cell junction; nucleus
Molecular Function: protein C-terminus binding; DNA binding
Biological Process: pro-B cell differentiation; positive regulation of neurogenesis; central nervous system development; V(D)J recombination; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; T cell differentiation in the thymus; DNA repair; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation; positive regulation of fibroblast proliferation; double-strand break repair; DNA ligation during DNA repair; response to gamma radiation; response to ionizing radiation; negative regulation of neuron apoptosis; positive regulation of ligase activity; response to DNA damage stimulus; response to X-ray
Research Articles on XRCC4
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Product Notes
The Mouse XRCC4 xrcc4 (Catalog #AAA9317012) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317012 ELISA Kit recognizes Mouse XRCC4. It is sometimes possible for the material contained within the vial of "X-ray repair complementing defective repair in Chinese hamster cells 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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