Human WW domain containing E3 ubiquitin protein ligase 1 ELISA Kit | WWP1 elisa kit

Human NEDD4-like E3 ubiquitin-protein ligase WWP1, WWP1 ELISA Kit

Cat. Num. AAA9325763

• Gene Names: WWP1; AIP5; Tiul1; hSDRP1
• Reactivity: Human
• Synonyms: WW domain containing E3 ubiquitin protein ligase 1; Human NEDD4-like E3 ubiquitin-protein ligase WWP1; WWP1 ELISA Kit; Human NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) ELISA kit; AIP5; DKFZp434D2111; Tiul1; hSDRP1; Nedd-4-like ubiquitin-protein ligase; TGIF-interacting ubiquitin ligase 1; atrophin-1 interacting protein 5; WWP1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13654239
• NCBI GeneID: 11059
• NCBI Accession #: NP_008944.1
• NCBI GenBank Nucleotide #: NM_007013.3
• UniProt Accession #: Q9H0M0; O00307; Q5YLC1; Q96BP4
• Molecular Weight: 105,202 Da
• NCBI Official Full Name: NEDD4-like E3 ubiquitin-protein ligase WWP1
• NCBI Official Synonym Full Names: WW domain containing E3 ubiquitin protein ligase 1
• NCBI Official Symbol: WWP1
• NCBI Official Synonym Symbols: AIP5; Tiul1; hSDRP1
• NCBI Protein Information: NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; atrophin-1 interacting protein 5; atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase
• UniProt Protein Name: NEDD4-like E3 ubiquitin-protein ligase WWP1
• Protein Family: NEDD4-like E3 ubiquitin-protein ligase
• UniProt Gene Name: WWP1
• UniProt Synonym Gene Names: AIP5; Tiul1
• UniProt Entry Name: WWP1_HUMAN

NCBI Description

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Description

WWP1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; entry of virus into host cell; central nervous system development; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; signal transduction; negative regulation of transcription, DNA-dependent; transmembrane transport