Protein Wnt-11b (wnt11b) Recombinant Protein | wnt11b recombinant protein
Recombinant Xenopus laevis Protein Wnt-11b (wnt11b)
NCBI and Uniprot Product Information
Uniprot Description
Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca2+ and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh. Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation. Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical Wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation. Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC. Acts redundantly with wnt11/wnt11r during pronephros induction.
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Product Notes
The wnt11b wnt11b (Catalog #AAA1123103) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-353, Full length protein. The amino acid sequence is listed below: IQWLGLTVNG SRVAWNESEH CRLLDGLVPD QSQLCKRNLE LMQSVVNAAK QTKLTCQMTL SDMRWNCSSV ENAPSFTPDL SKGTRESAFV YALASATLSH TIARACASGE LPTCSCGATP AEVPGTGFRW GGCGDNLHYG LNMGSAFVDA PMKSSKSAGT QATKIMNLHN NAVGRQVLMD SLETKCKCHG VSGSCSVKTC WKGLQDLPHI ANELKSKYLG ATKVIHRQTG TRRQLVPREL DIRPVRESEL VYLVSSPDYC TKNPKLGSYG TQDRLCNKTS VGSDSCNLMC CGRGYNAYTE TIVERCQCKY HWCCYVMCKK CERTVERYVC K. It is sometimes possible for the material contained within the vial of "Protein Wnt-11b (wnt11b), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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